INT32165

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2011
Negated 6
Speculated 3
Reported most in Body
Documents 92
Total Number 96
Disease Relevance 24.19
Pain Relevance 29.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 3
smooth muscle 2
macrophages 1
spinal cord 1
uterine 1
CALM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
complementary and alternative medicine 5565 100.00 Very High Very High Very High
agonist 156 99.98 Very High Very High Very High
antagonist 178 99.90 Very High Very High Very High
mu opioid receptor 45 99.76 Very High Very High Very High
Inflammation 86 99.28 Very High Very High Very High
Calcium channel 56 99.28 Very High Very High Very High
Potency 26 99.12 Very High Very High Very High
long-term potentiation 193 99.08 Very High Very High Very High
nMDA receptor 166 99.04 Very High Very High Very High
opiate 12 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 349 100.00 Very High Very High Very High
Hypersensitivity 33 99.70 Very High Very High Very High
Immunization 60 99.64 Very High Very High Very High
Hypertension 626 99.62 Very High Very High Very High
Rectal Cancer 72 99.52 Very High Very High Very High
Disease 409 99.32 Very High Very High Very High
Pressure And Volume Under Development 10 99.32 Very High Very High Very High
INFLAMMATION 93 99.28 Very High Very High Very High
Obesity 14 99.28 Very High Very High Very High
Mental Disorders 82 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This creates the potential for conflict, as CAM therapies may negatively interact with treatment, or contradictory advice from CAM practitioners may influence acceptance of or adherence to medical advice.
CAM Neg (negatively) Binding (interact) of associated with complementary and alternative medicine
1) Confidence 0.48 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266896 Disease Relevance 0.69 Pain Relevance 0.47
Thus, statutory regulation of CAM is not simply about granting professional recognition to CAM practitioners; it is first about protecting consumers' health and enabling them to make informed choices.
CAM Binding (recognition) of associated with complementary and alternative medicine
2) Confidence 0.47 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952302 Disease Relevance 0.07 Pain Relevance 0.23
As with other dihydropyridine calcium antagonists, an interaction with intracellular calcium reservoirs and calmodulin seems to be of minor importance.
calmodulin Binding (interaction) of in reservoirs associated with antagonist
3) Confidence 0.44 Published 1987 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 3154674 Disease Relevance 0 Pain Relevance 0.19
Thus, the amino terminal region of beta-endorphin, which is responsible for opiate activity, does not appear to contribute to the calmodulin interaction.
calmodulin Binding (interaction) of associated with opiate
4) Confidence 0.41 Published 1983 Journal Peptides Section Abstract Doc Link 6312432 Disease Relevance 0 Pain Relevance 0.22
Results from the latter approach, using peptide concentrations of 2-100 microM, demonstrated Ca2+-dependent equilibrium binding with an apparent stoichiometry of approximately 4 mol of peptide/mol of calmodulin and half-maximal binding at 15-20 microM.
calmodulin Binding (binding) of
5) Confidence 0.41 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 2934615 Disease Relevance 0 Pain Relevance 0.14
The concluding part of the paper addresses the need for a validation process that recognizes the inherent duality of approaches, methods, and belief patterns between CAM and biomedicine.

3.

CAM Binding (recognizes) of associated with complementary and alternative medicine
6) Confidence 0.41 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952302 Disease Relevance 0.08 Pain Relevance 0.50
The association of LRCH1 in European [14] has not been replicated in Asian [15] patients, and the association for CALM1 identified in Japanese hip OA [16] has not been detected in UK Caucasian patients [17].
CALM1 Binding (association) of in hip associated with osteoarthritis
7) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.43 Pain Relevance 0.21
In PEK II we matched 71 CON physicians who were not listed as members in any CAM medical association in Switzerland to AM physicians using a stratification technique based on geographic distribution.
CAM Binding (association) of in PEK associated with complementary and alternative medicine
8) Confidence 0.40 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2570361 Disease Relevance 0 Pain Relevance 0.05
The aim of this study is to explore academic doctors' views of CAM and its role within the NHS, along with the rationales they give for these views.
CAM Binding (views) of associated with complementary and alternative medicine
9) Confidence 0.37 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1896178 Disease Relevance 0.08 Pain Relevance 0.34
Second: they were reluctant to go outside of conventional medicine to seek information and support regarding CAM, having the hope and expectation that CAM information would be more easily available within the NHS and expressing disappointment when it was not.
CAM Binding (information) of associated with complementary and alternative medicine
10) Confidence 0.37 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2000907 Disease Relevance 0.08 Pain Relevance 0.34
According to Casey and Picherack, some conventional health professional organizations and commentators have taken the position that CAM practitioners should not be recognized by the state in the form of self-regulation unless and until they can demonstrate that their therapies or practice methods are evidence based [6].
CAM Binding (recognized) of associated with complementary and alternative medicine
11) Confidence 0.35 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952302 Disease Relevance 0 Pain Relevance 0.13
Age, religion and educational level were not associated with CAM use.
CAM Binding (associated) of associated with complementary and alternative medicine
12) Confidence 0.34 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2912779 Disease Relevance 0.30 Pain Relevance 0.95
CAM definition
CAM Binding (definition) of associated with complementary and alternative medicine
13) Confidence 0.33 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1884175 Disease Relevance 0 Pain Relevance 0.29
Still, these analyses should be interpreted with the various CAM definitions in mind.
CAM Binding (interpreted) of associated with complementary and alternative medicine
14) Confidence 0.33 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2394513 Disease Relevance 0 Pain Relevance 0.41
It is worth noting that osteopathic medicine is not generally considered as a form of CAM in the US and thus has been excluded from most CAM population studies conducted in the US [8].
CAM Binding (form) of associated with complementary and alternative medicine
15) Confidence 0.32 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2322980 Disease Relevance 0.42 Pain Relevance 0.21
The role of doctors' professional experiences in shaping their views of CAM
CAM Binding (views) of associated with complementary and alternative medicine
16) Confidence 0.32 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1896178 Disease Relevance 0 Pain Relevance 0.54
The latter was included as an 'extreme case' of a conventionally-trained doctor now entirely practising a form of CAM (homeopathy), as a point of comparison with doctors who were practising both CAM and conventional medicine within their general practice or were anticipated to be sceptical about CAM.
CAM Binding (practising) of associated with complementary and alternative medicine
17) Confidence 0.32 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1896178 Disease Relevance 0 Pain Relevance 0.26
We demonstrate that CAM has been successfully integrated in nine North American academic medical centers.
CAM Binding (integrated) of associated with complementary and alternative medicine
18) Confidence 0.32 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC1343546 Disease Relevance 0.26 Pain Relevance 0.32
The key themes we present should be used to help guide academic centers wishing to integrate CAM.
CAM Binding (integrate) of associated with complementary and alternative medicine
19) Confidence 0.32 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC1343546 Disease Relevance 0 Pain Relevance 0.08
At the present time, there is a lack of information regarding how CAM is being integrated into academic medical institutions, if it is being integrated at all [10].
CAM Binding (integrated) of associated with complementary and alternative medicine
20) Confidence 0.32 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC1343546 Disease Relevance 0 Pain Relevance 0.37

General Comments

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