INT3217

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Context Info
Confidence 0.62
First Reported 1978
Last Reported 2011
Negated 28
Speculated 12
Reported most in Abstract
Documents 154
Total Number 180
Disease Relevance 87.11
Pain Relevance 27.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 18
blood 11
liver 8
body 6
adipose tissue 6
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 708 100.00 Very High Very High Very High
agonist 370 100.00 Very High Very High Very High
Pain 41 100.00 Very High Very High Very High
opiate 34 100.00 Very High Very High Very High
Clonidine 19 100.00 Very High Very High Very High
Dynorphin 13 100.00 Very High Very High Very High
antidepressant 6 100.00 Very High Very High Very High
Antinociceptive 10 99.98 Very High Very High Very High
tolerance 912 99.90 Very High Very High Very High
Morphine 29 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 1863 100.00 Very High Very High Very High
INFLAMMATION 784 100.00 Very High Very High Very High
Body Weight 746 100.00 Very High Very High Very High
Hyperinsulinism 448 100.00 Very High Very High Very High
Aging 165 99.96 Very High Very High Very High
Targeted Disruption 1459 99.92 Very High Very High Very High
Impaired Glucose Tolerance 822 99.90 Very High Very High Very High
Pain 34 99.84 Very High Very High Very High
Obesity 2918 99.80 Very High Very High Very High
Chronic Renal Failure 32 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin levels were also unaffected by treatment but final corticosterone concentrations were consistently higher in fluoxetine-treated mice and lower in RU-486-treated mice.
Neg (unaffected) Regulation (unaffected) of Insulin associated with fluoxetine
1) Confidence 0.62 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2124625 Disease Relevance 0.68 Pain Relevance 0.65
OBJECTIVES: To investigate the effects of glucose and insulin alone or in combination with morphine, on pre-test day, on memory recall in mice.
Spec (investigate) Regulation (effects) of insulin
2) Confidence 0.61 Published 2004 Journal Psychopharmacology (Berl.) Section Body Doc Link 15042277 Disease Relevance 0 Pain Relevance 0
In contrast, morphine attenuated blood glucose and insulin during stress in C57BL/6J ob/ob but did not significantly affect either glucose or insulin during stress in lean C57BL/6J or A/J mice.
Neg (not) Regulation (affect) of insulin in blood associated with stress and morphine
3) Confidence 0.61 Published 1989 Journal Metab. Clin. Exp. Section Abstract Doc Link 2645504 Disease Relevance 0.51 Pain Relevance 0.69
We have investigated the effect of some antidepressant drugs on plasma glucose and insulin levels in normoglycaemic and alloxan-induced diabetic mice.
Spec (investigated) Regulation (effect) of insulin in plasma associated with antidepressant and diabetes mellitus
4) Confidence 0.61 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10454053 Disease Relevance 0.34 Pain Relevance 0.36
Effect of some antidepressants on glycaemia and insulin levels of normoglycaemic and alloxan-induced hyperglycaemic mice.
Regulation (Effect) of insulin associated with antidepressant
5) Confidence 0.61 Published 1999 Journal J. Pharm. Pharmacol. Section Title Doc Link 10454053 Disease Relevance 0.48 Pain Relevance 0.41
In lean mice, the same dose of dynorphin had no effect on plasma insulin concentrations but induced a small rise in glucose.
Neg (no) Regulation (effect) of insulin in plasma associated with dynorphin
6) Confidence 0.61 Published 1990 Journal Diabetes Section Abstract Doc Link 1976559 Disease Relevance 0.33 Pain Relevance 0.33
In conclusion, endogenous opioid substances might moderate the regulation of basal insulin levels in the mouse.
Regulation (regulation) of insulin associated with endogenous opioid
7) Confidence 0.56 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6090153 Disease Relevance 0 Pain Relevance 0.77
Acetaminophen-induced alterations in blood glucose and blood insulin levels in mice.
Regulation (alterations) of insulin in blood associated with paracetamol
8) Confidence 0.54 Published 1984 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Title Doc Link 6371954 Disease Relevance 0 Pain Relevance 0.45
Saline treatment did not appreciably alter blood insulin levels.
Regulation (alter) of insulin in blood
9) Confidence 0.54 Published 1984 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6371954 Disease Relevance 0 Pain Relevance 0.43
Effect of insulin and its combination with resveratrol or curcumin in attenuation of diabetic neuropathic pain: participation of nitric oxide and TNF-alpha.
Regulation (Effect) of insulin associated with pain, diabetes mellitus and neuropathic pain
10) Confidence 0.52 Published 2007 Journal Phytother Res Section Title Doc Link 17199240 Disease Relevance 1.21 Pain Relevance 0.74
Addition of stearate to HFP in the HFPS diet mimicked the effects of the high stearate HFL diet on hepatic insulin sensitivity.
Regulation (sensitivity) of insulin in HFL
11) Confidence 0.51 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.46 Pain Relevance 0
In addition to their low oxidative efficiency, saturated long chain FA are known to affect insulin sensitivity directly in a chain length dependent manner via a TLR4 dependent pathway [8-10].
Regulation (affect) of insulin
12) Confidence 0.51 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0 Pain Relevance 0
Plasma glucose and insulin responses to opiate receptor stimulation and antagonism were determined in 12-14 week old lean and obese-diabetic Aston ob/ob mice.
Regulation (responses) of insulin in Plasma associated with diabetes mellitus, obesity and opiate
13) Confidence 0.48 Published 1987 Journal Diabetologia Section Abstract Doc Link 3032718 Disease Relevance 0.58 Pain Relevance 0.49
Insulin administration at lower doses (0.5 and 1.0IU/kg, i.p.) had no effect on spatial working memory, however, it had significant spatial working memory impairment at the dose of 2.0IU/kg, i.p. in mice.
Neg (no) Regulation (effect) of Insulin associated with cognitive disorder
14) Confidence 0.45 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18840474 Disease Relevance 0.53 Pain Relevance 0.37
Effects of different doses of glucose and insulin on morphine state-dependent memory of passive avoidance in mice.
Regulation (Effects) of insulin associated with morphine
15) Confidence 0.45 Published 2004 Journal Psychopharmacology (Berl.) Section Title Doc Link 15042277 Disease Relevance 0 Pain Relevance 0.28
The effect of repeated administration of insulin on pain threshold and gamma-aminobutyric acid level in mouse brain.
Regulation (effect) of insulin in brain associated with pain and pain threshold
16) Confidence 0.45 Published 1987 Journal Acta Physiol Pol Section Title Doc Link 3331234 Disease Relevance 0.34 Pain Relevance 0.78
In ob/ob mice, the agonist-induced rise in glucose did not cause the insulin response, because insulin levels were not elevated by a glucose challenge.
Neg (not) Regulation (response) of insulin associated with obesity and agonist
17) Confidence 0.45 Published 1990 Journal Diabetes Section Abstract Doc Link 1976559 Disease Relevance 0.31 Pain Relevance 0.24
Effects of anesthetic agents and fasting duration on 18F-FDG biodistribution and insulin levels in tumor-bearing mice.
Regulation (Effects) of insulin associated with cancer
18) Confidence 0.44 Published 2005 Journal J. Nucl. Med. Section Title Doc Link 16157537 Disease Relevance 0.20 Pain Relevance 0.14
In contrast, the insulin response to 2-DG was not affected by capsaicin.
Neg (not) Regulation (affected) of insulin associated with qutenza
19) Confidence 0.44 Published 1992 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1378463 Disease Relevance 0.09 Pain Relevance 0.82
We examined the effect of insulin on the analgesic potency of DAMGO, a selective agonist of mu-opioid receptors, in mice which had been rendered diabetic by an injection of streptozotocin (STZ; 200 mg/kg, i.v.) 1 and 2 weeks previously.
Spec (examined) Regulation (effect) of insulin associated with diabetes mellitus, analgesic, mu opioid receptor, agonist and potency
20) Confidence 0.44 Published 1993 Journal Life Sci. Section Abstract Doc Link 8380216 Disease Relevance 0.30 Pain Relevance 0.74

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