INT321706

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.16 Pain Relevance 0

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency heart 2 Pten (Mus musculus)

Pain Link Frequency Relevance Heat Pain 1 5.00 isoflurane 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 14 99.92 Hypertrophy 15 61.28 Sprains And Strains 4 5.00 Dislocations 2 5.00 Frailty 2 5.00 Pain 1 5.00 Diabetes Mellitus 1 5.00 Insulin Resistance 1 5.00 Body Weight 1 5.00 Hyperinsulinism 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further, even though complete knockout of PTEN in muscle led to a reduction in insulin-stimulated phosphorylation of PKB in the EDL and increased wet mass in the TA and heart, the response to overload was unaltered.

Negative_regulation (reduction) of Phosphorylation (phosphorylation) of PTEN in heart associated with targeted disruption

1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.16 Pain Relevance 0

General Comments

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