INT321741

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Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsn) extracellular space (Gsn) vesicle-mediated transport (Gsn)
extracellular region (Gsn) cytoskeleton (Gsn) protein complex (Gsn)
Anatomy Link Frequency
hair cells 2
cochlea 1
row 1
vestibular hair cells 1
cochlear 1
Gsn (Mus musculus)
Pain Link Frequency Relevance Heat
Mechanotransduction 9 25.08 Quite Low
TRP channel 9 22.28 Low Low
medulla 18 6.08 Low Low
analgesia 9 5.00 Very Low Very Low Very Low
ketamine 9 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 63 81.12 Quite High
Aging 9 37.92 Quite Low
Deafness 18 9.80 Low Low
Body Weight 18 5.00 Very Low Very Low Very Low
Stress 18 5.00 Very Low Very Low Very Low
Wound Healing 9 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Hemorrhage 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction of gelsolin in the whirlin complex was confirmed and studied by investigating the localization of gelsolin in the whirler mutant (Whrnwi), which lacks whirlin, and also the shaker2 mutant (Myo15ash2), which lacks myosin XVa (Fig. 3).
Localization (localization) of gelsolin
1) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
We therefore sought to investigate the effects of the whirler and shaker2 mutants on the localization of gelsolin in hair cells.
Localization (localization) of gelsolin in hair cells
2) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.07 Pain Relevance 0
Further we examined the localisation of gelsolin across the stereocilia bundle rows.
Spec (examined) Localization (localisation) of gelsolin
3) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.06 Pain Relevance 0
The pattern of gelsolin at the apical hair cell surface strikingly mimics the previously reported localization of p55 [11].
Localization (localization) of gelsolin in hair cell
4) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.15 Pain Relevance 0
The localisation of twinfilin 2 in part mimics that of gelsolin in that the protein is not displayed in the tallest stereocilia row.
Localization (localisation) of gelsolin in row
5) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Confocal studies using a gelsolin antibody localized the protein to the stereocilia bundle of OHCs along the entire length of the cochlear duct (Fig. 2a).
Localization (localized) of gelsolin in cochlear duct
6) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.14 Pain Relevance 0
Localisation of gelsolin in cochlear and vestibular hair cells
Localization (Localisation) of gelsolin in vestibular hair cells
7) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.06 Pain Relevance 0
In conclusion, our observations on a number of combinations of double mutants support our hypothesis that the whirlin complex provides a scaffold for gelsolin that appropriately localized plays a role in controlling stereocilia elongation in the apical turns of the cochlea.


Localization (localized) of gelsolin in cochlea
8) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Localisation of gelsolin in cochlear and vestibular hair cells
Localization (Localisation) of gelsolin in cochlear
9) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.06 Pain Relevance 0

General Comments

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