INT321743

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.41
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsn) extracellular space (Gsn) vesicle-mediated transport (Gsn)
extracellular region (Gsn) cytoskeleton (Gsn) protein complex (Gsn)
Anatomy Link Frequency
hair cell 1
Gsn (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 91.36 High High
TRP channel 8 79.84 Quite High
Mechanotransduction 8 74.80 Quite High
medulla 16 5.00 Very Low Very Low Very Low
analgesia 8 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 56 99.60 Very High Very High Very High
Wound Healing 8 92.12 High High
INFLAMMATION 8 91.36 High High
Stress 16 89.64 High High
Hemorrhage 8 82.48 Quite High
Aging 8 66.64 Quite High
Deafness 16 15.36 Low Low
Body Weight 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also investigated given the interaction of p55 and gelsolin, whether or not the localisation of p55 is affected in a gelsolin knock-out mouse (Gsntm1Djk/Gsntm1Djk) [15].
gelsolin Binding (interaction) of associated with targeted disruption
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.24 Pain Relevance 0
We show that the actin capping and severing protein, gelsolin, is a part of the whirlin complex.
gelsolin Binding (part) of
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
We have shown on the basis of the knock-out phenotype that gelsolin, presumably via its capping and severing functions, acts to control actin polymerization and stereocilia development.
gelsolin Binding (capping) of associated with targeted disruption
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.45 Pain Relevance 0
Given the observed interactions between p55 and gelsolin we undertook localisation studies of gelsolin in the stereocilia bundle and at the apical hair cell surface.
gelsolin Binding (interactions) of in hair cell
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.07 Pain Relevance 0
Interaction of the proteins p55 and gelsolin
gelsolin Binding (Interaction) of
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
PIP2 plays an important role in the regulation of gelsolin function by binding to gelsolin and inhibiting its interaction with actin.
gelsolin Binding (binding) of
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.65 Pain Relevance 0.12
We confirmed the interaction between p55 and gelsolin both in vivo and in vitro.
gelsolin Binding (interaction) of
7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Gelsolin is an actin-binding and severing protein that regulates both actin assembly and disassembly [18], [19].
Gelsolin Binding (binding) of
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0

General Comments

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