INT321747

Context Info Confidence 0.44 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.32 Pain Relevance 0

cytosol (Gsn) extracellular space (Gsn) vesicle-mediated transport (Gsn) extracellular region (Gsn) cytoskeleton (Gsn) protein complex (Gsn)

Anatomy Link Frequency inner hair cells 2 Gsn (Mus musculus)

Pain Link Frequency Relevance Heat medulla 4 5.00 analgesia 2 5.00 Mechanotransduction 2 5.00 ketamine 2 5.00 TRP channel 2 5.00 Inflammation 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 14 99.20 Aging 2 47.84 Body Weight 4 5.00 Stress 4 5.00 Deafness 4 5.00 Wound Healing 2 5.00 INFLAMMATION 2 5.00 Hemorrhage 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In both the whirler and shaker2 mutants, expression of gelsolin is considerably reduced at P2 and is ablated from P5, similar to that seen for p55 [11] (Fig. 3).

Positive_regulation (ablated) of Gene_expression (expression) of gelsolin

1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.13 Pain Relevance 0

Gelsolin is confined to the outer hair cells and, like p55, is not expressed in inner hair cells (IHCs).

Positive_regulation (confined) of Neg (not) Gene_expression (expressed) of Gelsolin in inner hair cells

2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.19 Pain Relevance 0

General Comments

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