INT32176

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Context Info
Confidence 0.40
First Reported 1986
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.40
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
synapses 2
Adrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 12 100.00 Very High Very High Very High
depression 2 100.00 Very High Very High Very High
Neurotransmitter 3 98.92 Very High Very High Very High
Desipramine 9 98.32 Very High Very High Very High
tricyclic antidepressant 6 97.52 Very High Very High Very High
Serotonin 3 97.48 Very High Very High Very High
fluoxetine 3 96.28 Very High Very High Very High
Angina 2 75.00 Quite High
antagonist 1 35.04 Quite Low
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Stroke 1 76.32 Quite High
Cv General 3 Under Development 2 75.00 Quite High
Coronary Artery Disease 1 45.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lesser adverse impact of celiprolol on cardiac function may be attributable to ancillary cardiac stimulatory properties offsetting the cardiac depression after beta-adrenoceptor blockade.
Negative_regulation (depression) of Negative_regulation (blockade) of beta-adrenoceptor associated with depression
1) Confidence 0.40 Published 1986 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2935349 Disease Relevance 0.40 Pain Relevance 0.23
Vitamin E reduces antidepressant-related beta-adrenoceptor down-regulation in cultured cells.
Negative_regulation (reduces) of Negative_regulation (regulation) of beta-adrenoceptor associated with antidepressant
2) Confidence 0.24 Published 2006 Journal Planta Med. Section Title Doc Link 17109256 Disease Relevance 0 Pain Relevance 0.51
John's wort (SJW) extract reduced beta-AR numbers in cultured cells to a similar extent as DMI or the selective serotonin re-uptake inhibitor fluoxetine.
Negative_regulation (reduced) of Negative_regulation (numbers) of beta-AR associated with desipramine, serotonin and fluoxetine
3) Confidence 0.24 Published 2006 Journal Planta Med. Section Abstract Doc Link 17109256 Disease Relevance 0 Pain Relevance 0.57
Acute inhibition of neurotransmitter reuptake in central neuronal synapses, followed by a down-regulation of central postsynaptic beta-adrenoceptor (beta-AR) numbers were consistently observed in vivo, while a reduction in surface beta-AR density was found in cell cultures.
Negative_regulation (down) of Negative_regulation (regulation) of beta-AR in synapses associated with neurotransmitter
4) Confidence 0.24 Published 2006 Journal Planta Med. Section Abstract Doc Link 17109256 Disease Relevance 0 Pain Relevance 0.46

General Comments

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