INT32177

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Context Info
Confidence 0.14
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.89
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sptbn1) plasma membrane (Sptbn1) nucleus (Sptbn1)
protein complex (Sptbn1) cytoplasm (Sptbn1)
Anatomy Link Frequency
retinas 1
brain 1
Sptbn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 12 94.76 High High
fluoxetine 2 92.84 High High
Dopamine 3 86.32 High High
Neuropeptide 1 75.00 Quite High
Inflammatory mediators 10 73.84 Quite High
adenocard 10 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 6 97.84 Very High Very High Very High
Disease 4 82.56 Quite High
Stress 6 80.80 Quite High
Pressure And Volume Under Development 40 79.12 Quite High
INFLAMMATION 16 73.84 Quite High
Gliosis 14 64.96 Quite High
Papilledema 2 39.52 Quite Low
Diabetic Retinopathy 8 36.24 Quite Low
Retina Disease 50 5.00 Very Low Very Low Very Low
Sprains And Strains 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCPA treatment significantly decreased brain content of 5-HT and 5-hydroxyindole acetic acid (5-HIAA) while it caused significant increase and decrease in brain beta E and insulin levels, respectively, in both normal and diabetic rat.
Negative_regulation (decrease) of brain beta E in brain associated with diabetes mellitus
1) Confidence 0.14 Published 1986 Journal Horm. Res. Section Abstract Doc Link 2935473 Disease Relevance 0.51 Pain Relevance 0.34
In conclusion we show here that depletion of Dp71, a cytoskeleton protein associated to the membrane, leads to physiological alterations in Müller cells similar to those observed in injured or diseased retinas; this involves a mislocation of potassium and water channels (Kir4.1 and AQP4) and a consequent dysregulation of water transport through Müller cells.
Negative_regulation (depletion) of cytoskeleton protein in retinas
2) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.06 Pain Relevance 0
These alterations are associated with a strong decrease of Dp71, a cytoskeleton protein responsible for the localization and the clustering of Kir4.1 and AQP4.
Negative_regulation (decrease) of cytoskeleton protein
3) Confidence 0.00 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2754330 Disease Relevance 0.32 Pain Relevance 0.08

General Comments

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