INT321771

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.38
Pain Relevance 0

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isomerase activity (P4hb) endoplasmic reticulum (P4hb) protein complex (Gsn)
cytoplasm (Gsn) cytosol (Gsn) extracellular space (Gsn)
Anatomy Link Frequency
hair cell 2
inner ear 2
P4hb (Mus musculus)
Gsn (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 16 5.00 Very Low Very Low Very Low
analgesia 8 5.00 Very Low Very Low Very Low
Mechanotransduction 8 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
TRP channel 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 56 97.32 Very High Very High Very High
Aging 8 66.64 Quite High
Hemorrhage 8 20.24 Low Low
Deafness 16 15.36 Low Low
Stress 16 9.12 Low Low
Body Weight 16 5.00 Very Low Very Low Very Low
Wound Healing 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Firstly, p55 immunoprecipitations of inner ear lysates followed by western blotting with anti-gelsolin antibody demonstrated a specific interaction between p55 and gelsolin and indicated that the two proteins are part of the same complex in the inner ear (Fig. 1b).
p55 Binding (interaction) of gelsolin in inner ear
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
The interaction of the p55 GUK domain with several gelsolin constructs suggests that the GUK domain binds directly to a motif common to the gelsolin repeats.
p55 Binding (interaction) of gelsolin
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Interaction of the proteins p55 and gelsolin
p55 Binding (Interaction) of gelsolin
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
We confirmed the interaction between p55 and gelsolin both in vivo and in vitro.
p55 Binding (interaction) of gelsolin
4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Given the observed interactions between p55 and gelsolin we undertook localisation studies of gelsolin in the stereocilia bundle and at the apical hair cell surface.
p55 Binding (interactions) of gelsolin in hair cell
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.07 Pain Relevance 0
Firstly, p55 immunoprecipitations of inner ear lysates followed by western blotting with anti-gelsolin antibody demonstrated a specific interaction between p55 and gelsolin and indicated that the two proteins are part of the same complex in the inner ear (Fig. 1b).
p55 Binding (interaction) of gelsolin in inner ear
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Given the observed interactions between p55 and gelsolin we undertook localisation studies of gelsolin in the stereocilia bundle and at the apical hair cell surface.
p55 Binding (interactions) of gelsolin in hair cell
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.07 Pain Relevance 0
We also investigated given the interaction of p55 and gelsolin, whether or not the localisation of p55 is affected in a gelsolin knock-out mouse (Gsntm1Djk/Gsntm1Djk) [15].
p55 Binding (interaction) of gelsolin associated with targeted disruption
8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.24 Pain Relevance 0

General Comments

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