INT321775

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Whrn, Gsn) cytosol (Gsn) extracellular space (Gsn)
vesicle-mediated transport (Gsn) extracellular region (Gsn) cytoskeleton (Gsn)
Whrn (Mus musculus)
Gsn (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 25.52 Quite Low
medulla 8 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
Mechanotransduction 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
TRP channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 28 89.52 High High
Aging 4 61.52 Quite High
Hemorrhage 4 59.04 Quite High
Stress 8 47.92 Quite Low
INFLAMMATION 4 25.52 Quite Low
Wound Healing 4 24.08 Low Low
Body Weight 8 5.00 Very Low Very Low Very Low
Deafness 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical, ultrastructural and genetic data presented here demonstrate that gelsolin is a member of the whirlin complex and plays a role in stereocilia elongation.
whirlin Binding (complex) of gelsolin
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Taken together the biochemical, localization and mutant studies indicate that gelsolin is part of the whirlin complex.
whirlin Binding (complex) of gelsolin
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.22 Pain Relevance 0
Gelsolin is also part of the whirlin interactome and is lost from stereocilia when the critical scaffold protein whirlin is absent or when proteins such as myosin XVa are absent which are important for trafficking whirlin to the stereocilia tip.
whirlin Binding (interactome) of Gelsolin
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.20 Pain Relevance 0
The interaction of gelsolin in the whirlin complex was confirmed and studied by investigating the localization of gelsolin in the whirler mutant (Whrnwi), which lacks whirlin, and also the shaker2 mutant (Myo15ash2), which lacks myosin XVa (Fig. 3).
whirlin Binding (interaction) of gelsolin
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0

General Comments

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