INT321778

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (P4hb) endoplasmic reticulum (P4hb) plasma membrane (P4hb)
cilium (Whrn) cytoplasm (Whrn)
Anatomy Link Frequency
OHC 3
erythrocytes 1
filaments 1
hair cell 1
P4hb (Mus musculus)
Whrn (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 12 5.00 Very Low Very Low Very Low
analgesia 6 5.00 Very Low Very Low Very Low
Mechanotransduction 6 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
TRP channel 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Deafness 12 58.88 Quite High
Targeted Disruption 42 5.00 Very Low Very Low Very Low
Body Weight 12 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Wound Healing 6 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Hemorrhage 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whirlin interacts with p55 which is expressed exclusively in outer hair cells (OHC) in both the long stereocilia that make up the stereocilia bundle proper as well as surrounding shorter microvilli that will eventually regress.
p55 Binding (interacts) of Whirlin in OHC
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Whirlin interacts with p55 which is expressed exclusively in outer hair cells (OHC) in both the long stereocilia that make up the stereocilia bundle proper as well as the shorter microvilli that will eventually regress. p55 interacts with protein 4.1R in erythrocytes [12], and 4.1R is also expressed in stereocilia with an identical pattern to p55.
p55 Binding (interacts) of Whirlin in erythrocytes
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.06 Pain Relevance 0
In erythrocytes, p55 forms a tripartite complex with protein 4.1R and glycophorin C promoting the assembly of actin filaments and the interaction of whirlin with p55 indicates that it plays a similar role in OHC stereocilia.
p55 Binding (interaction) of whirlin in OHC
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Our previous findings that p55 is a member of the whirlin complex indicated that p55 plays a similar role in hair cell stereocilia [11].
p55 Binding (complex) of whirlin in hair cell
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
In erythrocytes, p55 forms a tripartite complex with protein 4.1R and glycophorin C promoting the assembly of actin filaments and the interaction of whirlin with p55 indicates that it plays a similar role in OHC stereocilia.
p55 Binding (interaction) of whirlin in OHC
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
In erythrocytes, p55 forms a tripartite complex with protein 4.1R and the cell-surface molecule, glycophorin C promoting the assembly of actin/spectrin filaments [12], and the interaction of whirlin with p55 indicates that it plays a similar role in OHC stereocilia.
p55 Binding (interaction) of whirlin in filaments
6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0

General Comments

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