INT321822

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.87
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD274) signal transduction (CD274) plasma membrane (CD274)
Anatomy Link Frequency
PDL-1 4
NK cell 4
Monocytes 2
stem cells 2
CD274 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 98 90.76 High High
Chronic pancreatitis 20 88.40 High High
COX2 60 69.28 Quite High
cytokine 128 64.20 Quite High
dexamethasone 12 54.32 Quite High
chemokine 14 12.00 Low Low
cINOD 14 5.00 Very Low Very Low Very Low
Immobilon 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 180 99.42 Very High Very High Very High
Cancer 512 95.28 Very High Very High Very High
Squamous Cell Carcinoma 48 91.64 High High
INFLAMMATION 104 90.76 High High
Pancreatitis 20 88.40 High High
Death 24 75.44 Quite High
Targeted Disruption 60 46.16 Quite Low
Carcinoma 4 36.32 Quite Low
Mouth Cancer 24 19.76 Low Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a partial maturation of the blood MDCs and PDCs in PDAC patients with significantly enhanced expression of CD83, CD40, B7H3, PDL-1, CCR6, and CCR7 and decreased expression of ICOSL, and DCIR.
Positive_regulation (enhanced) of Gene_expression (expression) of PDL-1 in PDL-1 associated with adenocarcinoma
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 1.24 Pain Relevance 0.21
The levels of PDL-1 and B7H3 were increased on MDCs pre surgery (median 245, median 5.1) and post surgery (median 252, median 5.2) compared to controls (median 164, median 3.3).
Positive_regulation (increased) of Gene_expression (levels) of PDL-1 in PDL-1
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.55 Pain Relevance 0
Moreover, when hMSCs were cultured with IL-2 treated NK cells alone or IL-2 treated NK cells with monocytes significant induction of B7H1 surface expression could be observed in surviving hMSCs (Fig. 5H).
Positive_regulation (induction) of Gene_expression (expression) of B7H1 in NK cells
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.08 Pain Relevance 0
Monocytes alone or untreated NK cells in the presence or absence of monocytes were not able to elevate B7H1 expression on the surface of hMSCs (data not shown).
Positive_regulation (elevate) of Gene_expression (expression) of B7H1 in Monocytes
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.06 Pain Relevance 0
The intensity of NK cell induced B7H1 expression on hMSCs were similar to that induced by the treatment of hMSCs with IFN-?
Positive_regulation (induced) of Gene_expression (expression) of B7H1 in NK cell
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.06 Pain Relevance 0.03
UCLA-OSCCs were found to have higher surface expression of B7H1 and EGF-R and moderate expression of CD44 and no surface expression of CD133 whereas UCLA-OSCSCs expressed no or very low expression of B7H1, EGF-R and increased expression of CD133 and CD44bright (please see Figure S1).
Positive_regulation (higher) of Gene_expression (expression) of B7H1
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.44 Pain Relevance 0
UCLA-OSCCs were found to have higher surface expression of B7H1 and EGF-R and moderate expression of CD44 and no surface expression of CD133 whereas UCLA-OSCSCs expressed no or very low expression of B7H1, EGF-R and increased expression of CD133 and CD44bright (please see Figure S1).
Positive_regulation (have) of Gene_expression (expression) of B7H1
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.44 Pain Relevance 0
by the NK cells and elevation of B7H1 surface expression on the stem cells (Figs. 4 and 5).
Positive_regulation (elevation) of Gene_expression (expression) of B7H1 in stem cells
8) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0 Pain Relevance 0.07

General Comments

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