INT321825

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (IL6) DNA binding (Stat3) cytoplasm (Stat3)
signal transducer activity (Stat3) cell proliferation (Stat3) signal transduction (Stat3)
Anatomy Link Frequency
NK cells 1
IL6 (Homo sapiens)
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 21 39.84 Quite Low
COX2 10 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 74 98.46 Very High Very High Very High
Mouth Cancer 4 85.92 High High
Squamous Cell Carcinoma 8 83.64 Quite High
Targeted Disruption 10 70.64 Quite High
Metastasis 2 33.72 Quite Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 2 5.00 Very Low Very Low Very Low
Solid Tumor 1 5.00 Very Low Very Low Very Low
Skin Diseases 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since blocking Stat3 function in tumor cells is also known to activate adaptive immunity [42], [43] it may be that IL-6 induced Stat3 is in part responsible for no/low activation of NK cells in the co-cultures of NK cells and either HEp2 cells or UCLA-1 or HOK-16B tumors.
IL-6 Positive_regulation (induced) of Stat3 in NK cells associated with cancer
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.58 Pain Relevance 0

General Comments

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