INT321825

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0

aging (IL6) DNA binding (Stat3) cytoplasm (Stat3) signal transducer activity (Stat3) cell proliferation (Stat3) signal transduction (Stat3)

Anatomy Link Frequency NK cells 1 IL6 (Homo sapiens) Stat3 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 21 39.84 COX2 10 5.00 Inflammation 5 5.00 dexamethasone 2 5.00 cINOD 2 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat Cancer 74 98.46 Mouth Cancer 4 85.92 Squamous Cell Carcinoma 8 83.64 Targeted Disruption 10 70.64 Metastasis 2 33.72 INFLAMMATION 6 5.00 Death 4 5.00 Cleidocranial Dysplasia 2 5.00 Solid Tumor 1 5.00 Skin Diseases 1 5.00

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Since blocking Stat3 function in tumor cells is also known to activate adaptive immunity [42], [43] it may be that IL-6 induced Stat3 is in part responsible for no/low activation of NK cells in the co-cultures of NK cells and either HEp2 cells or UCLA-1 or HOK-16B tumors.

IL-6 Positive_regulation (induced) of Stat3 in NK cells associated with cancer

1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.58 Pain Relevance 0

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