INT32184

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Context Info
Confidence 0.42
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.05
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col2a1) extracellular region (Col2a1) cytoplasm (Col2a1)
Anatomy Link Frequency
smooth muscle 1
articular cartilage 1
fibrocartilage 1
growth plate 1
Col2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 19 99.96 Very High Very High Very High
aspirin 2 98.60 Very High Very High Very High
cINOD 7 97.52 Very High Very High Very High
Inflammation 2 86.88 High High
rheumatoid arthritis 1 69.24 Quite High
Osteoarthritis 89 63.84 Quite High
Snapping jaw 1 63.16 Quite High
anesthesia 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Versed 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 8 100.00 Very High Very High Very High
Arthritis 13 98.76 Very High Very High Very High
Disease 20 98.40 Very High Very High Very High
Pressure And Volume Under Development 6 96.92 Very High Very High Very High
INFLAMMATION 4 93.32 High High
Peripheral Arterial Disease 1 89.76 High High
Injury 4 86.48 High High
Rupture 5 77.92 Quite High
Body Weight 32 76.40 Quite High
Rheumatoid Arthritis 3 69.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of Type II collagen arthritis can be induced by the prior intravenous treatment of rats with either Type II collagen or its constituent peptide alpha 1, (II) CB10.
Negative_regulation (Suppression) of Type II collagen associated with experimental arthritis and arthritis
1) Confidence 0.42 Published 1985 Journal Int J Tissue React Section Abstract Doc Link 2935508 Disease Relevance 0.80 Pain Relevance 0.48
None of these drugs reduced levels of antibody to type II collagen as determined by an ELISA procedure.
Negative_regulation (reduced) of type II collagen
2) Confidence 0.39 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6466005 Disease Relevance 0.80 Pain Relevance 0.39
Of these five, only auranofin inhibited antibody titer to type II collagen.
Negative_regulation (inhibited) of type II collagen
3) Confidence 0.39 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6466005 Disease Relevance 0.78 Pain Relevance 0.43
Proceeding anteriorly, staining for type I collagen increased, while that for type II collagen decreased.
Negative_regulation (decreased) of type II collagen
4) Confidence 0.33 Published 1996 Journal Arch. Oral Biol. Section Abstract Doc Link 9022924 Disease Relevance 0.15 Pain Relevance 0.06
The surgical procedure totally destroyed the enthesis, as evidenced by the absence of both tendon and collagen II-positive fibrocartilage (Fig. 1D).
Negative_regulation (absence) of collagen II-positive in fibrocartilage
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0.08 Pain Relevance 0
Hyaluronan treatment suppressed the loss of keratan sulfate and type II collagen after 30 km of strenuous running (Figure 5).


Negative_regulation (loss) of type II collagen
6) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374454 Disease Relevance 0.18 Pain Relevance 0.06
The growth plate contains a significant amount of collagen type II, which undergoes constant remodeling during ectopic bone formation and thereby contributes to systemic levels of collagen type II metabolites [17].
Negative_regulation (amount) of collagen type II in growth plate
7) Confidence 0.15 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0.06 Pain Relevance 0
Our findings show that ovariectomy induces a significant increase in the breakdown of collagen type II and subsequent articular cartilage erosion.
Negative_regulation (breakdown) of collagen type II in articular cartilage
8) Confidence 0.15 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0.20 Pain Relevance 0
The mRNA amount of procollagen alpha2(I), alpha-smooth muscle actin (alpha-SMA), tissue inhibitor of metalloproteinase (TIMP)-1, and TGF-beta1 was also increased by PDGF-BB.
Negative_regulation (inhibitor) of procollagen alpha2 in smooth muscle
9) Confidence 0.02 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0

General Comments

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