INT321842

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.34
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
CII 1
Ros1 (Mus musculus)
SCFV (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 41 90.16 High High
Osteoarthritis 41 89.60 High High
Arthritis 27 81.20 Quite High
Inflammation 22 52.16 Quite High
metalloproteinase 1 32.40 Quite Low
cytokine 3 28.64 Quite Low
abatacept 1 13.84 Low Low
antagonist 1 10.48 Low Low
Potency 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 41 90.16 High High
Frailty 42 89.60 High High
Arthritis 45 81.20 Quite High
Hyperglycemia 1 77.84 Quite High
Aging 2 60.52 Quite High
Stress 1 56.68 Quite High
INFLAMMATION 22 52.16 Quite High
Disease 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, assuming that ROS-modified CII is present only in the inflamed joints and using a phage display human antibody library, we identified a human single-chain variable fragment (scFv) that binds specifically to ROS-modified CII.
ROS-modified Binding (binds) of scFv in CII
1) Confidence 0.01 Published 2010 Journal Arthritis and Rheumatism Section Body Doc Link PMC2905615 Disease Relevance 1.34 Pain Relevance 0.54

General Comments

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