INT321902

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.05
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DAO) oxidoreductase activity (DAO) peroxisome (DAO)
cellular nitrogen compound metabolic process (DAO)
Anatomy Link Frequency
brain 6
liver 1
kidney 1
DAO (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 96 97.44 Very High Very High Very High
agonist 54 85.68 High High
nMDA receptor antagonist 18 50.20 Quite High
ketamine 6 43.32 Quite Low
Substantia nigra 12 38.08 Quite Low
Hippocampus 6 14.16 Low Low
Pain 48 5.00 Very Low Very Low Very Low
Bioavailability 18 5.00 Very Low Very Low Very Low
Eae 18 5.00 Very Low Very Low Very Low
Analgesic 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 132 99.36 Very High Very High Very High
Cognitive Disorder 78 92.64 High High
Sprains And Strains 12 76.40 Quite High
Psychosis 18 74.96 Quite High
Disease 18 61.52 Quite High
Pain 42 5.00 Very Low Very Low Very Low
Nociception 12 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Nephrotoxicity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, DAAO expression and enzyme activity has been reported to be increased in post mortem brain tissue samples from patients with schizophrenia compared to healthy controls.
Positive_regulation (increased) of Gene_expression (expression) of DAAO in brain associated with schizophrenia
1) Confidence 0.52 Published 2010 Journal The Open Medicinal Chemistry Journal Section Abstract Doc Link PMC2905773 Disease Relevance 0.57 Pain Relevance 0.08
They reported that DAAO activity and expression were upregulated in tissue from schizophrenic patients, however, the increases in expression and activity were not related to identified SNPs or the gene products G72 and G30 [34].
Positive_regulation (upregulated) of Gene_expression (expression) of DAAO associated with schizophrenia
2) Confidence 0.43 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.69 Pain Relevance 0.13
High levels of DAAO expression and enzyme activity are found in the mammalian liver, kidney, and brain although the expression pattern can vary between species.
Positive_regulation (levels) of Gene_expression (expression) of DAAO in brain
3) Confidence 0.40 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0 Pain Relevance 0
This hypothesis was tested by Burnet et al. 2008 who examined DAAO expression and activity in postmortem cerebellar tissue from schizophrenia patients and normal controls.
Spec (examined) Positive_regulation (examined) of Spec (examined) Gene_expression (expression) of DAAO associated with schizophrenia
4) Confidence 0.38 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.80 Pain Relevance 0.16
High levels of DAAO expression and enzyme activity are found in the mammalian liver, kidney, and brain although the expression pattern can vary between species.
Positive_regulation (levels) of in kidney Gene_expression (expression) of DAAO in brain
5) Confidence 0.14 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0 Pain Relevance 0
High levels of DAAO expression and enzyme activity are found in the mammalian liver, kidney, and brain although the expression pattern can vary between species.
Positive_regulation (levels) of in liver Gene_expression (expression) of DAAO in brain
6) Confidence 0.14 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0 Pain Relevance 0

General Comments

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