INT321910

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.96
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DAO) oxidoreductase activity (DAO) peroxisome (DAO)
cellular nitrogen compound metabolic process (DAO)
Anatomy Link Frequency
anterior 1
brain 1
cerebellum 1
DAO (Homo sapiens)
Pain Link Frequency Relevance Heat
Anterior cingulate 6 99.90 Very High Very High Very High
Analgesic 18 99.60 Very High Very High Very High
nMDA receptor 96 98.52 Very High Very High Very High
Acute pain 6 93.12 High High
Anterior cingulate cortex 6 89.08 High High
agonist 54 85.68 High High
Pain 48 81.48 Quite High
nMDA receptor antagonist 18 73.36 Quite High
Lasting pain 6 64.80 Quite High
ketamine 6 55.24 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 132 99.36 Very High Very High Very High
Nociception 12 98.04 Very High Very High Very High
Pain 42 93.12 High High
Cognitive Disorder 78 92.64 High High
Sprains And Strains 12 76.88 Quite High
Psychosis 18 74.96 Quite High
Disease 18 61.52 Quite High
Nephrotoxicity 6 49.20 Quite Low
Neuropathic Pain 6 43.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They reported that DAAO activity and expression were upregulated in tissue from schizophrenic patients, however, the increases in expression and activity were not related to identified SNPs or the gene products G72 and G30 [34].
Positive_regulation (upregulated) of DAAO associated with schizophrenia
1) Confidence 0.60 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.69 Pain Relevance 0.13
This finding suggests that increased D-serine metabolism resulting from increased DAAO activity may produce a reduction in NMDA receptor activity.
Positive_regulation (increased) of DAAO associated with nmda receptor
2) Confidence 0.52 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.86 Pain Relevance 0.18
In this regard, the paper by Duplantier et al 2009, indicated that free compound in brain may need to be several-fold greater than the in vitro IC50 before significant elevations in D-serine are observed, at least in the cerebellum which has a high level of DAAO activity [40].


Positive_regulation (level) of DAAO in cerebellum
3) Confidence 0.40 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.17 Pain Relevance 0.09
The G72 gene product was found to increase activity of DAAO and was subsequently termed D-amino acid oxidase activator (DAOA) [33].
Positive_regulation (increase) of DAAO
4) Confidence 0.38 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.89 Pain Relevance 0.26
Furthermore, DAAO expression and enzyme activity has been reported to be increased in post mortem brain tissue samples from patients with schizophrenia compared to healthy controls.
Positive_regulation (increased) of DAAO in brain associated with schizophrenia
5) Confidence 0.35 Published 2010 Journal The Open Medicinal Chemistry Journal Section Abstract Doc Link PMC2905773 Disease Relevance 0.57 Pain Relevance 0.08
These results were interpreted to indicate that decreasing D-serine (and presumably other D-amino acids) in the anterior cingulate via upregulating DAAO produces analgesic effects, and might suggest a nociceptive effect of inhibiting the enzyme.
Positive_regulation (upregulating) of DAAO in anterior associated with nociception, analgesic and anterior cingulate
6) Confidence 0.35 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.79 Pain Relevance 1.07

General Comments

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