INT321919

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) small molecule metabolic process (DAO) oxidoreductase activity (DAO)
Golgi apparatus (Gopc) plasma membrane (Gopc) peroxisome (DAO)
DAO (Homo sapiens)
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 3 100.00 Very High Very High Very High
nMDA receptor 16 79.24 Quite High
midbrain 1 55.12 Quite High
agonist 9 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 3 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 22 5.00 Very Low Very Low Very Low
Cognitive Disorder 13 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Psychosis 3 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
Nephrotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substitution of this compound with fluoro and chloro at positions 6 and 5 respectively and replacement of the 8 carbon atom with nitrogen culminated in an optimized compound (3, Fig. 1) that had improved oral bioavailability and maintained high affinity for rat and human DAAO (IC50 = 4nM), and weak affinity IC50 >14.5┬ÁM for DDO with negligible activity at the glycine / NMDA site.
DAAO Binding (affinity) of Fig associated with bioavailability
1) Confidence 0.02 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0 Pain Relevance 0.16

General Comments

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