INT321975

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.75
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Tgs1) nucleus (Tgs1) cytoplasm (Tgs1)
Anatomy Link Frequency
blood 2
Tgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 1 81.04 Quite High
cytokine 3 65.96 Quite High
Inflammation 25 62.56 Quite High
tolerance 1 37.12 Quite Low
fibrosis 9 26.92 Quite Low
Inflammatory marker 1 25.32 Quite Low
Chronic pancreatitis 2 19.92 Low Low
agonist 1 12.96 Low Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 149 96.20 Very High Very High Very High
Hypoglycemia 7 94.52 High High
Disease 10 90.88 High High
Lower Respiratory Tract Infection 3 88.88 High High
Pharyngitis 1 87.56 High High
Hypersensitivity 1 86.04 High High
INFLAMMATION 29 62.56 Quite High
Stress 6 60.40 Quite High
Impaired Glucose Tolerance 2 37.12 Quite Low
Body Weight 31 34.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects, together with a decrease in TGs content, might contribute to reduce pancreatic beta-cell deterioration, which is a feature of diabetes evolution to high deregulated states, and to alleviate the cardiovascular complications that accompany the evolution of the disease and that are responsible for the associated high mortality and morbidity rates worldwide [45].
Negative_regulation (decrease) of TGs associated with diabetes mellitus and disease
1) Confidence 0.14 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2905949 Disease Relevance 0.76 Pain Relevance 0.10
Biguanides promote peripheral uptake and utilization of blood glucose and they also exhibit a favorable effect on lipid profile i.e. a decrease in the TGs.[24] In a study conducted, B. prionitis has been reported as a potent hepatoprotective, showing a highly significant decrease in TGs.[8] This suggests that the mechanism of studied herb is similar to that of biguanides.
Negative_regulation (decrease) of TGs in blood
2) Confidence 0.04 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2907017 Disease Relevance 0.50 Pain Relevance 0
Biguanides promote peripheral uptake and utilization of blood glucose and they also exhibit a favorable effect on lipid profile i.e. a decrease in the TGs.[24] In a study conducted, B. prionitis has been reported as a potent hepatoprotective, showing a highly significant decrease in TGs.[8] This suggests that the mechanism of studied herb is similar to that of biguanides.
Negative_regulation (decrease) of TGs in blood
3) Confidence 0.04 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2907017 Disease Relevance 0.50 Pain Relevance 0

General Comments

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