INT32205

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Context Info
Confidence 0.11
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.82
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
ganglia 4
vas deferens 4
dorsal root ganglion 2
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 18 100.00 Very High Very High Very High
Rostral ventrolateral medulla 55 99.96 Very High Very High Very High
noradrenaline 18 99.84 Very High Very High Very High
Enkephalin 5 99.58 Very High Very High Very High
Desipramine 8 99.40 Very High Very High Very High
substance P 24 98.90 Very High Very High Very High
nMDA receptor 1 95.44 Very High Very High Very High
dorsal root ganglion 2 94.56 High High
Antinociceptive 4 93.84 High High
Spinal cord 3 92.48 High High
Disease Link Frequency Relevance Heat
Cold Sores 2 100.00 Very High Very High Very High
Cytomegalovirus Infection 1 100.00 Very High Very High Very High
Vibrio Infection 1 100.00 Very High Very High Very High
Hypoxia 3 98.00 Very High Very High Very High
Herpes Simplex Virus 2 97.16 Very High Very High Very High
Ganglion Cysts 2 94.56 High High
Death 62 94.52 High High
Pain 9 89.60 High High
Poisoning 7 89.32 High High
Nociception 2 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of agents that modulate intracellular release of calcium and protein kinase C (PKC) activation on noradrenaline (NA)-induced contractions of epididymal vas deferens in calcium-free/EGTA (1 mM) medium were investigated.
Regulation (modulate) of Positive_regulation (activation) of kinase in vas deferens associated with kinase c and noradrenaline
1) Confidence 0.11 Published 1999 Journal Life Sci. Section Abstract Doc Link 10416820 Disease Relevance 0 Pain Relevance 0.49
Pharmacomechanical coupling in rat vas deferens: effects of agents that modulate intracellular release of calcium and protein kinase C activation.
Regulation (modulate) of Positive_regulation (activation) of kinase in vas deferens associated with kinase c
2) Confidence 0.11 Published 1999 Journal Life Sci. Section Title Doc Link 10416820 Disease Relevance 0 Pain Relevance 0.61
In further studies, desipramine (10 microM) did not directly affect activation of the kinase by cAMP or maximum kinase catalytic activity.
Neg (not) Regulation (affect) of Positive_regulation (activation) of kinase associated with desipramine
3) Confidence 0.10 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2937646 Disease Relevance 0 Pain Relevance 0.52
Inhibition of glycine receptors occurred via a postsynaptic mechanism involving the activation of EP2 receptors, cholera-toxin-sensitive G-proteins and cAMP-dependent protein kinase.
Regulation (involving) of Positive_regulation (activation) of kinase associated with vibrio infection
4) Confidence 0.09 Published 2002 Journal Nat. Neurosci. Section Abstract Doc Link 11740501 Disease Relevance 0.33 Pain Relevance 0.62
c-Src kinase activation regulates preprotachykinin gene expression and substance P secretion in rat sensory ganglia.
Regulation (regulates) of Positive_regulation (activation) of kinase in ganglia associated with substance p
5) Confidence 0.07 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14622206 Disease Relevance 0.09 Pain Relevance 0.40
The hypothesis that the synthesis of SP in and secretion from the primary sensory ganglia are regulated by the activation of p60c-src kinase induced by IL-1beta was tested.
Regulation (regulated) of Positive_regulation (activation) of kinase in ganglia associated with substance p
6) Confidence 0.07 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0.08 Pain Relevance 0.40
Based on this model, our laboratory has previously demonstrated that nitric oxide (NO) generated by NO synthase I (NOS I) in RVLM, followed by activation of the soluble guanylyl cyclase/cyclic GMP/protein kinase G (PKG) cascade, is responsible for the pro-life phase; peroxynitrite formed by a reaction between NOS II-derived NO and superoxide anion underlies the pro-death phase [10-13].
Neg (NO) Regulation (followed) of Positive_regulation (activation) of kinase associated with rostral ventrolateral medulla and death
7) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 1.04 Pain Relevance 0.20
It has been reported that reactive oxygen species (ROS) can alter the cytoskeletal as well as tight junctional organization via activation of PI3-kinase and Akt [16].
Regulation (alter) of Positive_regulation (activation) of kinase
8) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.55 Pain Relevance 0.08
We transfected neurons of the dorsal root ganglion in vivo by footpad inoculation with 30 microl (3 x 10(7) p.f.u.) of a replication-incompetent (ICP4-deleted) herpes simplex virus (HSV) vector with a cassette containing a portion of the human proenkephalin gene coding for 5 met- and 1 leu-enkephalin molecules under the control of the human cytomegalovirus immediate-early promoter (HCMV IEp) inserted in the HSV thymidine kinase (tk) locus.
Regulation (control) of Positive_regulation (inserted) of kinase in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, cold sores, herpes simplex virus, cytomegalovirus infection and enkephalin
9) Confidence 0.01 Published 2001 Journal Gene Ther. Section Abstract Doc Link 11319622 Disease Relevance 0.73 Pain Relevance 0.79

General Comments

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