INT322068

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 4 Disease Relevance 3.28 Pain Relevance 0

nucleus (MYLK2) cytoplasm (MYLK2)

MYLK2 (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 4 5.00 palliative 4 5.00 metalloproteinase 4 5.00 imagery 4 5.00

Disease Link Frequency Relevance Heat Pancreatic Cancer 196 99.48 Cancer 148 99.06 Disease 32 5.00 Metastasis 12 5.00 Pancreatitis 12 5.00 Stomach Cancer 12 5.00 Lung Cancer 12 5.00 Adenocarcinoma 8 5.00 Non-small-cell Lung Cancer 8 5.00 Malignant Neoplastic Disease 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2, which have not previously been implicated in pancreatic cancer, were observed.

myosin light chain kinase 2 Binding (binding) of associated with pancreatic cancer

1) Confidence 0.06 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2906412 Disease Relevance 0.87 Pain Relevance 0

Proteomics analysis of serum protein profiling in pancreatic cancer patients by DIGE: up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2 Background

myosin light chain kinase 2 Binding (binding) of associated with pancreatic cancer

2) Confidence 0.06 Published 2010 Journal BMC Gastroenterol Section Title Doc Link PMC2906412 Disease Relevance 0.80 Pain Relevance 0

These two proteins 'mannose-binding lectin 2 and myosin light chain kinase 2' might be potential biomarkers for the diagnosis of the pancreatic cancer.

myosin light chain kinase 2 Binding (binding) of associated with pancreatic cancer

3) Confidence 0.06 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2906412 Disease Relevance 0.76 Pain Relevance 0

In an independent series of serum samples from 16 patients with pancreatic cancer and 16 non-cancer-bearing controls, increased levels of mannose-binding lectin 2 and myosin light chain kinase 2 were confirmed by western blot.

myosin light chain kinase 2 Binding (binding) of associated with cancer and pancreatic cancer

4) Confidence 0.06 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2906412 Disease Relevance 0.85 Pain Relevance 0

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