INT32208

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Context Info
Confidence 0.74
First Reported 1986
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 6.23
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lif) extracellular region (Lif)
Anatomy Link Frequency
uterine 2
neurons 2
back muscles 1
endometrium 1
neck 1
Lif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 127 100.00 Very High Very High Very High
Inflammation 56 100.00 Very High Very High Very High
Nerve growth factor 37 99.96 Very High Very High Very High
Acupuncture 135 99.84 Very High Very High Very High
qutenza 7 97.00 Very High Very High Very High
Dismenorea 8 96.52 Very High Very High Very High
anesthesia 10 94.56 High High
gABA 15 91.88 High High
Neuropeptide 25 89.40 High High
Neuropathic pain 3 88.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 81 100.00 Very High Very High Very High
Leukemia 27 100.00 Very High Very High Very High
Cancer 35 99.68 Very High Very High Very High
Wallerian Degeneration 1 99.36 Very High Very High Very High
Head & Neck Cancer 16 98.88 Very High Very High Very High
Optic Nerve Injuries 2 98.56 Very High Very High Very High
Spinal Cord Injury 71 98.40 Very High Very High Very High
Increased Venous Pressure Under Development 9 97.80 Very High Very High Very High
Dysmenorrhea 8 96.52 Very High Very High Very High
Nociception 2 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also highlight the possibility that a sympathetic sprouting signal may be derived from the periphery, as NGF, LIF and IL-6 are all produced as a result of Wallerian degeneration, and can be retrograde transported to the DRG.
Gene_expression (produced) of LIF in sympathetic associated with nerve growth factor and wallerian degeneration
1) Confidence 0.74 Published 1999 Journal Pain Section Abstract Doc Link 10491979 Disease Relevance 0.31 Pain Relevance 0.30
OBJECTIVE: To determine whether the expression of leukemia inhibitory factor during the implantation window in endometrial tissue and uterine flushing fluid of patients with adenomyosis differs from that of healthy fertile women.
Gene_expression (expression) of leukemia inhibitory factor in uterine associated with leukemia, dismenorea and increased venous pressure under development
2) Confidence 0.60 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19361790 Disease Relevance 0.52 Pain Relevance 0.17
Leukemia inhibitory factor protein expression was evaluated with semiquantitative immunohistochemistry.
Gene_expression (expression) of Leukemia inhibitory factor
3) Confidence 0.60 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19361790 Disease Relevance 0.14 Pain Relevance 0
The present study showed that AC improved the expression of LIF and OPN proteins in a rat's uterus during implantation period.
Gene_expression (expression) of LIF in uterus associated with acupuncture
4) Confidence 0.60 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2957198 Disease Relevance 0.29 Pain Relevance 0.15
In the absence of LIF, within the population of heat-sensitive neurons, the proportion of neurons also GAL-IR increased from 17% to 32% between 6h and 1 day in culture to stay at this level.
Neg (absence) Gene_expression (absence) of LIF in neurons
5) Confidence 0.60 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18258298 Disease Relevance 0.65 Pain Relevance 0.83
Then they were homogenized in phosphate buffered distilled water, and LIF levels were detected in the homogenized fluid by ELISA method.
Gene_expression (detected) of LIF
6) Confidence 0.59 Published 2002 Journal Gynecol. Endocrinol. Section Abstract Doc Link 12012626 Disease Relevance 0.22 Pain Relevance 0.09
In conclusion, AC was found in our study to ameliorate the uterine environment, by advancing the gland development, reducing the high-serum E2 concentration, and increasing the glandular area and the expression of receptivity markers: LIF and OPN proteins during the implantation period in CC-induced model.
Gene_expression (expression) of LIF in gland associated with acupuncture
7) Confidence 0.53 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2957198 Disease Relevance 0 Pain Relevance 0.21
Staining intensity of LIF in AC group was weaker than that of NC group (optical density: 0.171 ± 0.027 versus 0.246 ± 0.023), but higher than that of CC group (optical density: 0.135 ± 0.023).The same trend of immunoreactivity of OPN was observed in the three groups.
Gene_expression (intensity) of LIF associated with acupuncture
8) Confidence 0.53 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2957198 Disease Relevance 0 Pain Relevance 0.19
The electromyography fatigue indices revealed that the Sorensen fatigue test and UPP produced more fatigue in the back muscles than the LIF.
Gene_expression (produced) of LIF in back muscles
9) Confidence 0.52 Published 2005 Journal Arch Phys Med Rehabil Section Body Doc Link 15827924 Disease Relevance 0.12 Pain Relevance 0
RESULT(S): Leukemia inhibitory factor levels were significantly lower in the uterine flushing fluid of patients with adenomyosis with a history of infertility.
Gene_expression (levels) of Leukemia inhibitory factor in uterine
10) Confidence 0.46 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19361790 Disease Relevance 0.13 Pain Relevance 0
Leukemia inhibitory factor messenger RNA expression in eutopic endometrium was quantified by real-time reverse transcriptase polymerase chain reaction.
Gene_expression (expression) of Leukemia inhibitory factor in endometrium
11) Confidence 0.46 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19361790 Disease Relevance 0.15 Pain Relevance 0
Other data also suggest that LIF and CNTF might be effective neuroprotective agents for TPS neurons and maintain axonal regeneration after SCI [72-74].
Gene_expression (neurons) of LIF in neurons associated with spinal cord injury
12) Confidence 0.38 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.60 Pain Relevance 0.25
Gene array analysis validated by QRT-PCR revealed an increase in the expression of LIF and TGFß1 as well as their corresponding receptors, LIFR, gp130 and AK5 in the SVZ at 7 days recovery from H/I.
Gene_expression (expression) of LIF
13) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.23 Pain Relevance 0.09
-treated cells was unaffected by the presence of either EGF, LIF or a combination of both LIF and TGF?
Gene_expression (presence) of LIF
14) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.07
1, as compared to those treated with LIF alone or with EGF or TGF?
Gene_expression (alone) of LIF
15) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.06
1, as compared to those treated with LIF alone or with EGF or TGF?
Gene_expression (treated) of LIF
16) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.06
Our analysis revealed no significant difference in the expression of Lifr, a receptor for LIF and a co-receptor for CNTF, or Cntfr, the primary receptor for CNTF.
Gene_expression (expression) of LIF
17) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.23 Pain Relevance 0.10
-endorphin from corticotrophs); and (v) several cytokines, such as IL-6, LIF, MIF, follistatin and NO, produced in FS cells and targeting several cell types, and annexin-1 from FS cells mediating the rapid negative feedback of glucocorticoid on ACTH secretion.
Gene_expression (produced) of LIF in corticotrophs associated with cytokine
18) Confidence 0.19 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.13
LIF production in response to phytohemagglutinin was significantly less in the cancer patients compared to normal subjects (p less than .001). beta-endorphin significantly enhanced LIF production in the cancer patients (p = .01) to levels that did not differ significantly from normal levels.
Gene_expression (production) of LIF associated with cancer
19) Confidence 0.18 Published 1986 Journal Otolaryngol Head Neck Surg Section Abstract Doc Link 2938055 Disease Relevance 0.60 Pain Relevance 0.15
Earlier demonstrations of impaired cellular immunity and impaired lymphokine production in patients with cancer of the head and neck prompted an investigation of the in vitro effects of beta-endorphin on the production of leukocyte migration inhibitory factor (LIF) in 29 patients with head and neck cancer and in 45 normal subjects.
Gene_expression (production) of LIF in neck associated with head & neck cancer
20) Confidence 0.18 Published 1986 Journal Otolaryngol Head Neck Surg Section Abstract Doc Link 2938055 Disease Relevance 0.50 Pain Relevance 0.17

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