INT32209

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.41
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
extracellular region (Mif) nucleus (Mif) cytoplasm (Mif)
Anatomy Link Frequency
neck 3
head 1
Mif (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 4 91.76 High High
Neuropeptide 6 90.72 High High
Inflammation 40 88.96 High High
Opioid 2 87.84 High High
dexamethasone 2 65.80 Quite High
cytokine 16 59.20 Quite High
cINOD 2 43.00 Quite Low
chemokine 2 14.16 Low Low
cva 2 8.52 Low Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Head & Neck Cancer 8 98.96 Very High Very High Very High
Cancer 88 98.90 Very High Very High Very High
INFLAMMATION 46 91.76 High High
Aging 2 88.32 High High
Apoptosis 6 85.80 High High
Starvation 2 80.48 Quite High
Disease 20 78.28 Quite High
Squamous Cell Carcinoma 2 75.00 Quite High
Toxicity 2 72.60 Quite High
Death 8 72.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our expanding knowledge of MIF biology now includes a greater understanding of its ability to both directly promote tumour growth and indirectly create a nurturing local tumour microenvironment, as well as insight into the genetic regulation of MIF expression.
Regulation (regulation) of Gene_expression (expression) of MIF associated with cancer
1) Confidence 0.59 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.07 Pain Relevance 0.12
Over-expression of MIF down regulated p53 levels and suppressed nuclear localization, thereby prohibiting its transcriptional activity.
Regulation (regulated) of Gene_expression (expression) of MIF
2) Confidence 0.44 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.33 Pain Relevance 0.19
Earlier demonstrations of impaired cellular immunity and impaired lymphokine production in patients with cancer of the head and neck prompted an investigation of the in vitro effects of beta-endorphin on the production of leukocyte migration inhibitory factor (LIF) in 29 patients with head and neck cancer and in 45 normal subjects.
Regulation (effects) of Gene_expression (production) of leukocyte migration inhibitory factor in neck associated with head & neck cancer
3) Confidence 0.02 Published 1986 Journal Otolaryngol Head Neck Surg Section Abstract Doc Link 2938055 Disease Relevance 0.50 Pain Relevance 0.18
Earlier demonstrations of impaired cellular immunity and impaired lymphokine production in patients with cancer of the head and neck prompted an investigation of the in vitro effects of beta-endorphin on the production of leukocyte migration inhibitory factor (LIF) in 29 patients with head and neck cancer and in 45 normal subjects.
Regulation (effects) of in head Gene_expression (production) of leukocyte migration inhibitory factor in neck associated with head & neck cancer
4) Confidence 0.01 Published 1986 Journal Otolaryngol Head Neck Surg Section Abstract Doc Link 2938055 Disease Relevance 0.50 Pain Relevance 0.18

General Comments

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