INT32210

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 27
Disease Relevance 28.48
Pain Relevance 7.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
extracellular region (Mif) nucleus (Mif) cytoplasm (Mif)
Anatomy Link Frequency
macrophage 3
blood vessels 2
plasma 1
intestine 1
neck 1
Mif (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 391 100.00 Very High Very High Very High
cytokine 154 100.00 Very High Very High Very High
rheumatoid arthritis 121 99.98 Very High Very High Very High
Neuropeptide 7 99.78 Very High Very High Very High
fibrosis 15 99.44 Very High Very High Very High
Neuritis 6 98.96 Very High Very High Very High
chemokine 35 98.12 Very High Very High Very High
lidocaine 10 97.88 Very High Very High Very High
analgesia 2 96.04 Very High Very High Very High
Morphine 7 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 659 100.00 Very High Very High Very High
INFLAMMATION 455 100.00 Very High Very High Very High
Rheumatoid Arthritis 121 99.98 Very High Very High Very High
Intestinal Cancer 15 99.96 Very High Very High Very High
Hypoxia 120 99.92 Very High Very High Very High
Malignant Neoplastic Disease 30 99.92 Very High Very High Very High
Breast Cancer 61 99.84 Very High Very High Very High
Syndrome 10 99.84 Very High Very High Very High
Cystic Fibrosis 15 99.44 Very High Very High Very High
Adult Respiratory Distress Syndrome 57 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MIF protein is found to be over-expressed in a number of cancers and expression levels have been found to correlate with disease severity and invasiveness.
Gene_expression (expressed) of MIF protein associated with cancer and disease
1) Confidence 0.75 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.46 Pain Relevance 0.11
Our expanding knowledge of MIF biology now includes a greater understanding of its ability to both directly promote tumour growth and indirectly create a nurturing local tumour microenvironment, as well as insight into the genetic regulation of MIF expression.
Gene_expression (expression) of MIF associated with cancer
2) Confidence 0.75 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.06 Pain Relevance 0.12
Over-expression of MIF down regulated p53 levels and suppressed nuclear localization, thereby prohibiting its transcriptional activity.
Gene_expression (expression) of MIF
3) Confidence 0.75 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.27 Pain Relevance 0.16
Its release coincides with, and is induced by adrenocorticotrophic hormone and its ability to override the anti-inflammatory effects of this hormone suggested an inbuilt regulatory mechanism.9 This ability to promote inflammation while hindering the anti-inflammatory effects of glucocorticoids was implicated in the pathogenesis of acute respiratory distress syndrome (ARDS).12 Direct association between MIF expression levels and degrees of disease pathogenesis in a number of inflammatory diseases was revealed through analysis of genetic variation within the MIF gene.13–15 Allelic variation within a repeat region found upstream of the MIF promoter, determines efficiency of expression of the protein.
Gene_expression (expression) of MIF in respiratory associated with inflammation, adult respiratory distress syndrome and disease
4) Confidence 0.75 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 0.89 Pain Relevance 0.26
In vitro exposure of mouse lymphocytes and macrophages for 24 h to noncytotoxic doses of lidocaine (10(-4) to 10(-6)M) resulted in inhibition of random macrophage motility and in an interference with the production of macrophage migration inhibitory factor or with its interaction with the cell surface.
Gene_expression (production) of migration inhibitory factor in macrophages associated with lidocaine
5) Confidence 0.68 Published 1985 Journal Immunopharmacology Section Abstract Doc Link 3894285 Disease Relevance 0 Pain Relevance 0.48
For example, in a mouse model of intestinal cancer, MIF expression was found to be increased in tumour tissue relative to normal intestine.
Gene_expression (expression) of MIF in intestine associated with cancer and intestinal cancer
6) Confidence 0.65 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.50 Pain Relevance 0.10
In cystic fibrosis patients, this increase in MIF production associated with carrying the 6 and 7 repeat variants was associated with enhanced end-organ injury.
Gene_expression (production) of MIF associated with fibrosis, injury and cystic fibrosis
7) Confidence 0.65 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.26 Pain Relevance 0.30
stabilization induced by hypoxia.42 MIF expression has been found to be up-regulated during hypoxia, with a HRE found in the 5?
Gene_expression (expression) of MIF associated with hypoxia
8) Confidence 0.65 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.28 Pain Relevance 0.03
Rheumatoid arthritis patients carrying the 6 and 7 repeat variants had both higher basal levels of MIF and higher levels following stimulation with forskolin or serum.
Gene_expression (levels) of MIF associated with rheumatoid arthritis
9) Confidence 0.65 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.41 Pain Relevance 0.31
MIF-deficient cells were found to be resistant to p53-associated Ras oncogenic transformation which is mediated downstream through Rb and E2F.
Gene_expression (resistant) of MIF
10) Confidence 0.65 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.25 Pain Relevance 0.13
MIF protein is found to be over-expressed in a number of cancers and expression levels have been found to correlate with disease severity and invasiveness.
Gene_expression (expressed) of MIF protein associated with cancer and disease
11) Confidence 0.65 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.46 Pain Relevance 0.11
Transformation induced by Ras was restored upon deletion of p53.25,26

MIF receptor signalling and tumour pathogenesis

Gene_expression (signalling) of MIF receptor associated with cancer
12) Confidence 0.65 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.43 Pain Relevance 0.12
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Gene_expression (genes) of Mif associated with chemokine
13) Confidence 0.59 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.80 Pain Relevance 0.59
The data show increased MIF plasma levels in GBS patients as compared to healthy controls (p<0.0001) and a progressive increase of MIF circulating concentration with patient's disability (p<0.0001).
Gene_expression (levels) of MIF in plasma associated with syndrome
14) Confidence 0.59 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 16171874 Disease Relevance 1.34 Pain Relevance 0.69
In relation to cancer pathogenesis, investigators have sought to define this enzymatic activity by both utilizing catalytically inactive recombinant proteins in vitro and in animal models by using a transgenic mouse expressing enzymatically inactive MIF.59 The P1G mouse expresses a mutated MIF where a terminal proline has been replaced by a glycine resulting in specific loss of this enzymatic activity.
Gene_expression (expresses) of MIF associated with targeted disruption and cancer
15) Confidence 0.57 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 0.75 Pain Relevance 0.04
Through the activation of MAP kinases MIF enhances the differentiation of endothelial cells to blood vessels.45,46 In human breast cancer cells, MIF over-expression correlates with IL-8 and VEGF expression associated with angiogenesis.47

MIF, enzymatic activity and tumour progression

Gene_expression (progression) of MIF in blood vessels associated with cancer and breast cancer
16) Confidence 0.57 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.03 Pain Relevance 0.05
Individuals carrying five copies of the CATT repeat element were found to display lower MIF levels, with those possessing increasing numbers of repeats (6, 7 or 8) having a corresponding increase in expression.
Gene_expression (levels) of MIF
17) Confidence 0.57 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.07 Pain Relevance 0.28
Though over-expressed in the microarray, only a marginal increase in expression of Mif was observed at 96 hr post infection by PCR, where increases in inflammation and neutrophil migration were also observed.
Gene_expression (expression) of Mif in neutrophil associated with inflammation and infection
18) Confidence 0.53 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.70 Pain Relevance 0.44
In addition inflammatory genes e.g., Fcer1g, and Mif were also over-expressed at 72 and 96 hr post infection.
Gene_expression (expressed) of Mif associated with inflammation and infection
19) Confidence 0.53 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.55 Pain Relevance 0.24
Through the activation of MAP kinases MIF enhances the differentiation of endothelial cells to blood vessels.45,46 In human breast cancer cells, MIF over-expression correlates with IL-8 and VEGF expression associated with angiogenesis.47

MIF, enzymatic activity and tumour progression

Gene_expression (over-expression) of MIF in blood vessels associated with cancer and breast cancer
20) Confidence 0.51 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.20 Pain Relevance 0.04

General Comments

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