INT322132

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.39
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp, Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Mbp (Rattus norvegicus)
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 3 87.64 High High
Hyperalgesia 12 78.60 Quite High
agonist 18 72.88 Quite High
dorsal root ganglion 48 38.60 Quite Low
Taxol 90 21.92 Low Low
Pain 39 5.00 Very Low Very Low Very Low
imagery 36 5.00 Very Low Very Low Very Low
Neuropathic pain 12 5.00 Very Low Very Low Very Low
Mechanosensation 9 5.00 Very Low Very Low Very Low
Mechanotransduction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 3 87.64 High High
Nociception 42 82.60 Quite High
Hyperalgesia 12 78.60 Quite High
Neuroblastoma 3 39.88 Quite Low
Ganglion Cysts 48 38.60 Quite Low
Pain 36 5.00 Very Low Very Low Very Low
Neuropathic Pain 15 5.00 Very Low Very Low Very Low
Adhesions 9 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To understand if tubulin binding affects actin binding and vice versa, we performed a competition experiment between soluble tubulin and soluble actin for the binding to MBP-TRPV4-Ct.
MBP Binding (binding) of TRPV4
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0
in the MBP-TRPV4-Ct complex, both in presence and absence of Ca2+.
MBP Binding (complex) of TRPV4
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.39 Pain Relevance 0.27
Soluble tubulin and actin were added to MBP-TRPV4-Ct sequentially before being analysed for their binding to TRPV4 (Fig. 1f).
MBP Spec (analysed) Binding (binding) of TRPV4
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0

General Comments

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