INT32222

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Context Info
Confidence 0.37
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.23
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG)
nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)
Anatomy Link Frequency
immune cells 2
serotonergic neurons 2
CLN 2
T lymphocytes 2
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 22 100.00 Very High Very High Very High
antinociception 42 99.92 Very High Very High Very High
Antihyperalgesic 2 99.80 Very High Very High Very High
dexamethasone 1 99.64 Very High Very High Very High
Opioid 148 99.28 Very High Very High Very High
Nucleus accumbens 6 96.24 Very High Very High Very High
fluoxetine 1 93.28 High High
Endogenous opioid 43 89.20 High High
antagonist 13 88.80 High High
Dopamine 1 88.00 High High
Disease Link Frequency Relevance Heat
Infection 8 98.80 Very High Very High Very High
Endometriosis 13 98.12 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 96.60 Very High Very High Very High
Stroke 13 95.92 Very High Very High Very High
Immunodeficiency 2 95.48 Very High Very High Very High
Stress 39 94.48 High High
Hyperalgesia 30 87.92 High High
Attention Deficit Hyperactivity Disorder 2 85.88 High High
Disease 7 78.32 Quite High
INFLAMMATION 79 68.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to evaluate the expression of the neo-angiogenic marker endoglin and its localization in tissues of normal and endometriotic patients as well as to compare it with one new angiogenic marker candidate - S100A13.
Negative_regulation (evaluate) of Gene_expression (expression) of endoglin associated with endometriosis
1) Confidence 0.37 Published 2005 Journal Reprod Biol Section Abstract Doc Link 15821778 Disease Relevance 0.35 Pain Relevance 0.13
A significant correlation between the beta-END reduction in the response and the reduction in the HRSD score (r=.656; p<.001) was observed.
Negative_regulation (reduction) of Gene_expression (reduction) of beta-END
2) Confidence 0.26 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 18725263 Disease Relevance 0 Pain Relevance 0
Moreover, the CLN effect was blocked by long-term dexamethasone treatment, which inhibits beta-END synthesis.
Negative_regulation (inhibits) of Gene_expression (synthesis) of beta-END in CLN associated with dexamethasone
3) Confidence 0.11 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2938979 Disease Relevance 0.16 Pain Relevance 0.31
For example, even though the control END levels in Fig. 4A and Fig. 4B were comparable, the END levels after different doses of POMC-MIDGE-NLS varied between the two graphs.
Negative_regulation (doses) of Gene_expression (levels) of END
4) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.49 Pain Relevance 0.38
Antibodies to both END and ENK could reverse the antihyperalgesic effect observed after release of these peptides from immune cells was stimulated using CRF or IL-1?
Negative_regulation (reverse) of Gene_expression (Antibodies) of END in immune cells associated with antihyperalgesic and enkephalin
5) Confidence 0.04 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.12 Pain Relevance 1.65
The end-effector force, the velocity of the end-effector, the work toward target and the work away from target in the tangential direction of the tunnel are presented in Figure 3.
Negative_regulation (presented) of Gene_expression (force) of end-effector
6) Confidence 0.02 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2965146 Disease Relevance 0.10 Pain Relevance 0
A statistically significant decrease in the beta-End synthesis was observed in these patients, as compared to a control group of 19 healthy subjects, but this decrease was not related to the CD4+T lymphocytes number.
Negative_regulation (decrease) of Gene_expression (synthesis) of beta-End in T lymphocytes
7) Confidence 0.01 Published 1995 Journal Riv Eur Sci Med Farmacol Section Abstract Doc Link 8766783 Disease Relevance 0.37 Pain Relevance 0.09
In addition, posterior hypothalamic lesion inhibited the PRL response but not the ACTH and beta-END responses to activation of serotonergic neurons induced by ip administration of the 5-HT precusor 5-hydroxytryptophan in combination with the 5-HT re-uptake inhibitor fluoxetine.
Negative_regulation (inhibited) of Gene_expression (response) of beta-END in serotonergic neurons associated with fluoxetine
8) Confidence 0.00 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 9892850 Disease Relevance 0.57 Pain Relevance 0.25
V) beta-END levels in the ventricular CSF tend to decrease parallel to a drop in conciousness as well as with longlasting comatous states.
Negative_regulation (decrease) of Gene_expression (levels) of beta-END
9) Confidence 0.00 Published 1988 Journal Neurosurg Rev Section Abstract Doc Link 3244418 Disease Relevance 0.08 Pain Relevance 0.08

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