INT322237

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.30
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Agtrap) endoplasmic reticulum (Agtrap) plasma membrane (Agtrap)
Agtrap (Mus musculus)
Hcm (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 6 96.08 Very High Very High Very High
Serotonin 48 50.00 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
5HT 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophic Cardiomyopathy 126 100.00 Very High Very High Very High
Left Ventricular Hypertrophy 57 97.32 Very High Very High Very High
Hypertrophy 24 93.04 High High
Disease 18 84.88 Quite High
Coronary Heart Disease 42 79.16 Quite High
Hypertension 21 5.00 Very Low Very Low Very Low
Myocardial Infarction 21 5.00 Very Low Very Low Very Low
Cardiovascular Disease 12 5.00 Very Low Very Low Very Low
Heart Disease 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association between the AT1R SNP and HCM was significant (p = 0.015), but the OR for allele C-carriers was 1.56 and the lower limit of CI (1.09) was close to 1.
AT1R Binding (association) of HCM associated with hypertrophic cardiomyopathy
1) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.72 Pain Relevance 0.09
The AT1R 1166 A/C polymorphism was associated with HCM in patients without sarcomeric gene mutations.
AT1R Binding (associated) of HCM associated with hypertrophic cardiomyopathy
2) Confidence 0.10 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.71 Pain Relevance 0.03
Third, we found a significant association between the AT1R and familial HCM in patients without sarcomeric gene mutations, but our classification of familial/sporadic cases was incomplete because we did not perform ECG or echocardiographic examination to all the first degree relatives of our patients.
AT1R Binding (association) of HCM associated with hypertrophic cardiomyopathy
3) Confidence 0.10 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.86 Pain Relevance 0.07

General Comments

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