INT322282

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (PSMD2) cytosol (PSMD2) nucleoplasm (PSMD2)
small molecule metabolic process (PSMD2) cellular nitrogen compound metabolic process (PSMD2)
Anatomy Link Frequency
neutrophils 1
PSMD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 80 89.48 High High
Inflammatory mediators 4 85.68 High High
rheumatoid arthritis 1 75.44 Quite High
cytokine 9 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 100.00 Very High Very High Very High
Dengue Hemorrhagic Fever 205 97.90 Very High Very High Very High
INFLAMMATION 90 89.48 High High
Dengue 88 76.48 Quite High
Atherosclerosis 2 76.20 Quite High
Rheumatoid Arthritis 1 75.44 Quite High
Cardiovascular Disease 1 74.56 Quite High
Sepsis 5 73.56 Quite High
Schistosomiasis 2 68.88 Quite High
Cestode Infection 8 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A putative neutrophil origin of this gene expression pattern is however supported by the over-expression in DSS patients blood cells of transcripts encoding other neutrophil-related molecules such as the MMP8 matrix metalloprotease, CEACAM-6, CEACAM-8 and CD99L2 adhesion molecules (Tables 4 and S2) involved in the recruitment of neutrophils to vascular endothelia.
Localization (metalloprotease) of S2 in neutrophils associated with dengue hemorrhagic fever and adhesions
1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.18 Pain Relevance 0.22
Of these a general serine protein inhibitor and a Kunitz type 8 of serine protein inhibitors were identified within the group of predicted secreted molecules (Table S2).
Localization (secreted) of S2
2) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3006133 Disease Relevance 0.24 Pain Relevance 0

General Comments

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