INT322389

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hist1h1t) chromosome (Hist1h1t) nucleus (Hist1h1t)
intracellular (Hist1h1t) DNA binding (Hist1h1t)
Hist1h1t (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 3 99.68 Very High Very High Very High
opioid receptor 393 99.62 Very High Very High Very High
Morphine 9 99.48 Very High Very High Very High
antagonist 111 97.00 Very High Very High Very High
Enkephalin 18 85.88 High High
agonist 33 75.36 Quite High
analgesia 60 50.00 Quite Low
Antinociceptive 18 31.24 Quite Low
Analgesic 48 24.00 Low Low
Pain 42 7.24 Low Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

96 22.80 Low Low
Pain 33 7.24 Low Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

45 5.00 Very Low Very Low Very Low
Nociception 21 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Colitis 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, while CTAP reverses AKT phosphorylation induced by DAMGO, it fails to inhibit the effects exerted by H2S on AKT, indicating that, despite MOR trans-activation, H2S-induced AKT phosphorylation is due to a direct effect of the gas on the PI3K/AKT pathway.
Phosphorylation (phosphorylation) of H2S associated with antagonist and opioid receptor
1) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.37
opioid receptors leads to their phosphorylation, internalization, desensitization and down-regulation and represents one the main biochemical substrates of morphine tolerance, the fact that H2S causes a short-lasting receptor phosphorylation and that rapid receptor phosphorylation (min) does not directly correlate with the relatively slow rate of desensitization (h) of MOR induced by morphine [27], suggests that this mediator is unlikely to play a role in long term desensitization of MOR and could still be a pharmacological target in situation of MOR desensitization
Phosphorylation (phosphorylation) of H2S associated with tolerance, opioid receptor and morphine
2) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.82
Effect of H2S on AKT phosphorylation
Phosphorylation (phosphorylation) of H2S
3) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.48

General Comments

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