INT32239

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Context Info
Confidence 0.67
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 38
Total Number 39
Disease Relevance 6.86
Pain Relevance 9.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
neurons 7
dentate gyrus 3
pyramidal neurons 2
subiculum 2
hilus 2
Car3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 295 100.00 Very High Very High Very High
amygdala 17 100.00 Very High Very High Very High
Action potential 21 99.84 Very High Very High Very High
Hippocampus 274 99.68 Very High Very High Very High
Opioid 21 98.88 Very High Very High Very High
Enkephalin 8 98.60 Very High Very High Very High
fluoxetine 1 98.46 Very High Very High Very High
Desipramine 1 98.16 Very High Very High Very High
Limbic system 6 98.12 Very High Very High Very High
ischemia 11 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 7 100.00 Very High Very High Very High
Stress 153 99.64 Very High Very High Very High
Convulsion 57 99.56 Very High Very High Very High
Infection 112 98.36 Very High Very High Very High
Cv Unclassified Under Development 11 97.28 Very High Very High Very High
Toxicity 6 93.52 High High
Urological Neuroanatomy 43 90.28 High High
Epilepsy 29 90.00 High High
Bordatella Infection 3 89.96 High High
Depression 31 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although CA3 PCs displayed a larger variability in their phase-voltage relations, a voltage-dependent phase shift (90-180 degrees) could be observed in CA3 PCs as well. 5.
Gene_expression (displayed) of CA3 in PCs associated with pyramidal cell
1) Confidence 0.67 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8395591 Disease Relevance 0 Pain Relevance 0.55
Proteins related to oxidative stress response such as carbonic anhydrase III (CA3) and 60kDa heat shock protein (HSP60), and energy metabolism such as adenylate kinase 4 (AK4) were found.
Gene_expression (found) of carbonic anhydrase III associated with stress and shock
2) Confidence 0.65 Published 2006 Journal J Toxicol Sci Section Abstract Doc Link 16538043 Disease Relevance 0.75 Pain Relevance 0.07
Proteins related to oxidative stress response such as carbonic anhydrase III (CA3) and 60kDa heat shock protein (HSP60), and energy metabolism such as adenylate kinase 4 (AK4) were found.
Gene_expression (found) of CA3 associated with stress and shock
3) Confidence 0.65 Published 2006 Journal J Toxicol Sci Section Abstract Doc Link 16538043 Disease Relevance 0.75 Pain Relevance 0.07
The maximal slope of the Ca(2+)-dependent action potential of the CA3 neurons, which were evoked in the presence of 8-CPT (1 microM), nifedipine (20 microM), TTX (0.5 microM), and tetraethyl ammonium chloride (20 mM), decreased by 12 +/- 6% of the control 4 min after the onset of in vitro ischemia.
Gene_expression (evoked) of CA3 in neurons associated with action potential and ischemia
4) Confidence 0.65 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11535660 Disease Relevance 0.86 Pain Relevance 0.63
When maximal dentate activation was present bursts of population spikes were also recorded in CA3 and CA1.
Gene_expression (recorded) of CA3 in spikes
5) Confidence 0.59 Published 1994 Journal Epilepsy Res. Section Abstract Doc Link 8088253 Disease Relevance 0 Pain Relevance 0.03
An important aim of this study is to assess the feasibility of dual transneuronal labeling, for which we have chosen the bilateral projection of CA3 to CA1.
Gene_expression (projection) of CA3
6) Confidence 0.58 Published 2008 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2629710 Disease Relevance 0.16 Pain Relevance 0.08
Here with both treatments, the l-CMRg in the claustrum, septal nucleus, amygdala, and ventral areas of CA1 and CA3 of the hippocampus remained at control values.
Gene_expression (claustrum) of CA3 in ventral associated with hippocampus and amygdala
7) Confidence 0.57 Published 1984 Journal Anesthesiology Section Abstract Doc Link 6703383 Disease Relevance 0.07 Pain Relevance 0.23
0.30 at 12 weeks], the CA3 region [F(2 21)?
Gene_expression (region) of CA3
8) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2572851 Disease Relevance 0 Pain Relevance 0.22
The injections removed both wings of the dentate gyrus along with the mossy fibers without substantially changing the pyramidal cells of field CA3 (Fig. 4A,B).
Gene_expression (changing) of CA3 in wings associated with pyramidal cell
9) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770848 Disease Relevance 0 Pain Relevance 0.20
These immunochemical and electroencephalographic data are compatible with single-unit electrophysiological studies showing predominant excitations of hippocampal pyramidal neurons in CA1 and CA3 fields produced by iontophoresis of endorphins or enkephalins.
Gene_expression (produced) of CA3 in pyramidal neurons associated with pyramidal cell and enkephalin
10) Confidence 0.51 Published 1986 Journal Adv Neurol Section Abstract Doc Link 2939697 Disease Relevance 0.09 Pain Relevance 0.96
Since it is well established that CA3 projections not only target CA1 but also project to the lateral septum bilaterally (Witter and Amaral, 2004), we assessed labeling in the latter structure as well in order to determine which intermediate pathway mediated the second order infection of CA3 neurons.
Gene_expression (projections) of CA3 in neurons associated with infection
11) Confidence 0.51 Published 2008 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2629710 Disease Relevance 0.17 Pain Relevance 0.08
It is also unlikely that CA3 neurons might be labeled as a result of primary infection of interneurons in CA1, since most of our first order CA1 neurons showed the typical morphology of pyramidal cells.
Gene_expression (neurons) of CA3 in pyramidal cells associated with pyramidal cell and infection
12) Confidence 0.51 Published 2008 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2629710 Disease Relevance 0.10 Pain Relevance 0.12
It is however unlikely, in view of the established time needed to cross a single synapse, that the observed labeling in CA3 after 6?
Spec (observed) Gene_expression (observed) of CA3 in synapse
13) Confidence 0.51 Published 2008 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2629710 Disease Relevance 0.08 Pain Relevance 0.13
It was shown that c-Fos expression in the CA1 region, the CA2 and CA3 regions, and the dentate gyrus of the hippocampus was significantly increased by treadmill running and naloxone, a nonselective opioid receptors antagonist, treatment enhanced treadmill exercise-induced increase of hippocampal c-Fos expression.
Gene_expression (expression) of CA3 in dentate gyrus associated with antagonist, narcan, opioid receptor and hippocampus
14) Confidence 0.50 Published 2003 Journal Life Sci. Section Abstract Doc Link 14550853 Disease Relevance 0 Pain Relevance 0.43
In conclusion, the effect of OFQ on VGCCs expressed in hippocampal CA3 and CA1 neurons may play an important role in the regulation of hippocampal cell excitability and neurotransmitter release.
Gene_expression (expressed) of CA3 in neurons associated with neurotransmitter
15) Confidence 0.48 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8824306 Disease Relevance 0.24 Pain Relevance 0.37
Consonant with this, the I(h) channel blocker ZD7288 at 10 ┬ÁM [43], the half-maximal inhibitory concentration in CA1 [44], reduced the initial segment of the AHP recorded from CA3 neurons (recorded at ?
Gene_expression (neurons) of CA3 in neurons
16) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770848 Disease Relevance 0 Pain Relevance 0.10
The mossy fibers, in this view, not only serve to connect granule cells, and their cortical input, to field CA3 but also act as isolated elements with unusual properties appropriate for initiating autonomous waves.
Gene_expression (field) of CA3 in mossy fibers
17) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770848 Disease Relevance 0 Pain Relevance 0.12
The presence of I(AHP) was consistent with the high expression level of the apamin-sensitive SK2 subunit transcript in CA3 st. radiatum interneurons as detected by in situ hybridization.
Gene_expression (expression) of CA3 in interneurons
18) Confidence 0.44 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11353015 Disease Relevance 0 Pain Relevance 0.28
In situ hybridization showed a high level of RSEP1 expression in the CA1, CA3 and dentate gyrus regions of the hippocampus and the small sensory neurons in the dorsal horn, as well as the large neurons in the ventral horn of the spinal cord.
Gene_expression (expression) of CA3 in horn associated with dorsal horn, hippocampus and spinal cord
19) Confidence 0.39 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16176350 Disease Relevance 0.78 Pain Relevance 1.13
Opioid-mediated inhibition may provide an explanation for the resistance of the immature CA3 region to seizure-induced damage.
Gene_expression (resistance) of CA3 associated with convulsion and opioid
20) Confidence 0.38 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9263604 Disease Relevance 0.44 Pain Relevance 0.41

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