INT322410

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.08
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hist1h1t) Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1)
intracellular (Hist1h1t) DNA binding (Hist1h1t) signal transducer activity (OPRM1)
Anatomy Link Frequency
neuronal 2
Hist1h1t (Rattus norvegicus)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 393 100.00 Very High Very High Very High
agonist 33 98.32 Very High Very High Very High
Enkephalin 18 97.82 Very High Very High Very High
antagonist 111 97.44 Very High Very High Very High
analgesia 60 91.96 High High
Analgesic 48 86.60 High High
Opioid 36 80.20 Quite High
Visceral pain 45 78.28 Quite High
Antinociceptive 18 69.44 Quite High
Pain 42 45.44 Quite Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

45 78.28 Quite High
Pain 33 45.44 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

96 5.00 Very Low Very Low Very Low
Nociception 21 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Colitis 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
receptor-selective enkephalin analog DAMGO and H2S confirm these data demonstrating that, in the neuronal-cell line SKNMC, both DAMGO and H2S induce MOR activation and phosphorylation leading to interaction between MOR and ?
H2S Positive_regulation (induce) of Phosphorylation (phosphorylation) of MOR in neuronal associated with opioid receptor and enkephalin
1) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 1.12
However, while CTAP reverses AKT phosphorylation induced by DAMGO, it fails to inhibit the effects exerted by H2S on AKT, indicating that, despite MOR trans-activation, H2S-induced AKT phosphorylation is due to a direct effect of the gas on the PI3K/AKT pathway.
H2S Positive_regulation (induced) of Phosphorylation (phosphorylation) of MOR associated with antagonist and opioid receptor
2) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.37
Further, and similarly to DAMGO, H2S causes a robust, time- and concentration-dependent phosphorylation of MOR in Ser(377), a site that is specifically required to induce receptor activation and internalization by DAMGO.
H2S Positive_regulation (causes) of Phosphorylation (phosphorylation) of MOR associated with opioid receptor
3) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.83

General Comments

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