INT322411

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.25
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hist1h1t) Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1)
intracellular (Hist1h1t) DNA binding (Hist1h1t) signal transducer activity (OPRM1)
Anatomy Link Frequency
neuronal 2
Hist1h1t (Rattus norvegicus)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 393 100.00 Very High Very High Very High
Enkephalin 18 97.82 Very High Very High Very High
antagonist 111 97.44 Very High Very High Very High
analgesia 60 95.08 Very High Very High Very High
Opioid 36 91.24 High High
Antinociceptive 18 90.84 High High
Pain 42 88.80 High High
Analgesic 48 87.68 High High
agonist 33 84.48 Quite High
antinociception 15 78.64 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

96 99.20 Very High Very High Very High
Nociception 21 98.60 Very High Very High Very High
Pain 33 88.80 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

45 78.28 Quite High
Disease 3 5.00 Very Low Very Low Very Low
Colitis 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H2S caused MOR transactivation and internalization in SKNMCs by a mechanism that required AKT phosphorylation.
H2S Positive_regulation (caused) of Positive_regulation (transactivation) of MOR associated with opioid receptor
1) Confidence 0.00 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2908066 Disease Relevance 0.09 Pain Relevance 1.76
H2S induces MOR activation and internalization
H2S Positive_regulation (induces) of Positive_regulation (activation) of MOR associated with opioid receptor
2) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0.30 Pain Relevance 0.76
receptor-selective enkephalin analog DAMGO and H2S confirm these data demonstrating that, in the neuronal-cell line SKNMC, both DAMGO and H2S induce MOR activation and phosphorylation leading to interaction between MOR and ?
H2S Positive_regulation (induce) of Positive_regulation (activation) of MOR in neuronal associated with opioid receptor and enkephalin
3) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 1.11

General Comments

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