INT322412

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
PPBP (Homo sapiens)
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 111 100.00 Very High Very High Very High
opioid receptor 393 96.04 Very High Very High Very High
agonist 33 81.52 Quite High
analgesia 60 51.84 Quite High
Morphine 9 21.56 Low Low
tolerance 3 12.72 Low Low
Analgesic 48 5.00 Very Low Very Low Very Low
Visceral pain 45 5.00 Very Low Very Low Very Low
Pain 42 5.00 Very Low Very Low Very Low
Opioid 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

96 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

45 5.00 Very Low Very Low Very Low
Pain 33 5.00 Very Low Very Low Very Low
Nociception 21 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Colitis 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, while CTAP reverses AKT phosphorylation induced by DAMGO, it fails to inhibit the effects exerted by H2S on AKT, indicating that, despite MOR trans-activation, H2S-induced AKT phosphorylation is due to a direct effect of the gas on the PI3K/AKT pathway.
CTAP Negative_regulation (reverses) of Phosphorylation (phosphorylation) of AKT associated with antagonist and opioid receptor
1) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.40
However, CTAP failed to inhibit AKT phosphorylation induced by Na2S (Figure 7, panel C and D, p < 0.05 versus control).
CTAP Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of AKT associated with antagonist
2) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.65
AKT phosphorylation induced by DAMGO was reversed by CTAP (Figure 7C).
CTAP Negative_regulation (reversed) of Phosphorylation (phosphorylation) of AKT associated with antagonist
3) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.60

General Comments

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