INT322454

Context Info Confidence 0.10 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.60 Pain Relevance 0

cell morphogenesis (Bcl6) nucleus (Bcl6) intracellular (Bcl6) DNA binding (Bcl6)

Bcl6 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 5 5.00 dexamethasone 4 5.00 Potency 3 5.00 cytokine 2 5.00 withdrawal 2 5.00 palliative 1 5.00 ketamine 1 5.00 anesthesia 1 5.00 fibrosis 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 5 99.84 Lymphatic System Cancer 22 95.16 Cancer 57 94.68 Hyperplasia 1 86.92 Hypoxia 13 86.88 Leukemia 9 86.32 Disease 38 76.68 Acute Promyelocytic Leukemia 1 75.56 Genetic Translocation 1 67.52 Cv Unclassified Under Development 13 63.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Bcl-6, a homolog of the up-regulated Bazf gene, has been found to be up-regulated in breast cancer and associated with higher HIF-1?

Positive_regulation (up-regulated) of Bcl-6 associated with breast cancer

1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.52 Pain Relevance 0

These complexes cause activation of BCL-6 resulting in transcriptional silencing.

Positive_regulation (activation) of BCL-6

2) Confidence 0.05 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 1.09 Pain Relevance 0

General Comments

This test has worked.