INT322474

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 4.82
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (PGAP1) nuclease activity (PGAP1)
PGAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 294 100.00 Very High Very High Very High
Inflammation 18 99.40 Very High Very High Very High
Perioperative pain 36 98.56 Very High Very High Very High
antagonist 12 94.24 High High
Pain 42 93.12 High High
anesthesia 36 87.08 High High
central sensitization 18 85.60 High High
Analgesic 36 85.04 High High
Potency 6 84.24 Quite High
Opioid 24 79.20 Quite High
Disease Link Frequency Relevance Heat
Pharyngitis 204 100.00 Very High Very High Very High
INFLAMMATION 24 99.40 Very High Very High Very High
Post Operative Pain 36 98.56 Very High Very High Very High
Nociception 24 97.56 Very High Very High Very High
Hyperalgesia 6 91.04 High High
Pain 42 81.00 Quite High
Injury 30 80.80 Quite High
Hoarseness 18 77.60 Quite High
Cough 18 77.00 Quite High
Adenocarcinoma 6 56.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We expected that this dose of ketamine might affect POST, but it did not.
Spec (might) Regulation (affect) of POST associated with pharyngitis and ketamine
1) Confidence 0.38 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908222 Disease Relevance 0.47 Pain Relevance 1.27
In conclusion, low dose ketamine did not affect POST as a 0.5 mg/kg preinduction bolus followed by an intraoperative infusion of 10 µg/kg/min.
Neg (not) Regulation (affect) of POST associated with pharyngitis and ketamine
2) Confidence 0.38 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908222 Disease Relevance 0.99 Pain Relevance 0.55
We did not observe an effect on POST and did not detect a difference in postoperative pain VAS or the doses of fentanyl administered.
Regulation (effect) of POST associated with pharyngitis and perioperative pain
3) Confidence 0.38 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908222 Disease Relevance 0.58 Pain Relevance 1.29
However, intravenous low dose ketamine had no effect on the incidence and severity of POST.
Neg (no) Regulation (effect) of POST associated with pharyngitis and ketamine
4) Confidence 0.19 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908222 Disease Relevance 0.72 Pain Relevance 0.78
Therefore, we cannot reach a firm conclusion about the effect of low-dose ketamine on POST.



Regulation (effect) of POST associated with pharyngitis and ketamine
5) Confidence 0.17 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908222 Disease Relevance 0.91 Pain Relevance 0.38
Our results suggest that topical application, and not systemic ketamine, may influence POST, reduce local inflammation, and mediate the peripheral anti-nociceptive effect.
Spec (may) Regulation (influence) of POST associated with nociception, pharyngitis, inflammation and ketamine
6) Confidence 0.17 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908222 Disease Relevance 1.14 Pain Relevance 0.79

General Comments

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