INT322525

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CB) signal transduction (PIK3CB) cell adhesion (PIK3CB)
nucleus (PIK3CB) cytoplasm (PIK3CB)
PIK3CB (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 55 99.16 Very High Very High Very High
Stress 2 91.40 High High
Hypoxia 3 91.12 High High
Glioma 26 73.52 Quite High
Renal Cell Carcinoma 29 71.76 Quite High
Tuberous Sclerosis 1 64.40 Quite High
Renal Cancer 2 46.52 Quite Low
Retinoblastoma 1 18.08 Low Low
Pneumonia 16 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PI3K-AKT-mTOR pathway is dys-regulated in many cancers.16 In response to extracellular stimuli, PI3K phosphorylates the 3?
Phosphorylation (phosphorylates) of PI3K associated with cancer
1) Confidence 0.42 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.85 Pain Relevance 0
We observed a decrease in phosphorylation of PI3K, AKT and FOXO3a (Ser318) (Fig. 4A) protein along with decreased activity of Cdk2 (Fig. 3B) with the RNAi treatments.
Phosphorylation (phosphorylation) of PI3K
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.24 Pain Relevance 0

General Comments

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