INT322529

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOXO3) embryo development (FOXO3) DNA binding (FOXO3)
response to stress (FOXO3) cytoplasm (FOXO3) cytosol (FOXO3)
Anatomy Link Frequency
nucleus 1
FOXO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 28.48 Quite Low
Disease Link Frequency Relevance Heat
Glioma 104 93.72 High High
Apoptosis 36 85.84 High High
Hyperplasia 8 77.92 Quite High
Colon Cancer 8 56.52 Quite High
Cancer 140 40.80 Quite Low
INFLAMMATION 4 28.08 Quite Low
Metastasis 8 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Retinoblastoma 4 5.00 Very Low Very Low Very Low
Lung Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For FOXO proteins to be active, newly synthesized FOXO3a must translocate to the nucleus, which is further influenced by its phosphorylation status.
Localization (translocate) of FOXO3a in nucleus
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Localization (localization) of FOXO3a
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.54 Pain Relevance 0
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Localization (localization) of FOXO3a
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.54 Pain Relevance 0
More importantly, LY294002-treatment caused FOXO3a nuclear accumulation.
Localization (accumulation) of FOXO3a
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox