INT322543

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.84
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (FOXO3, Cdkn1b) cytosol (FOXO3, Cdkn1b) nucleus (FOXO3, Cdkn1b)
endosome (Cdkn1b) nucleoplasm (FOXO3) embryo development (FOXO3)
Anatomy Link Frequency
osteoblasts 1
FOXO3 (Homo sapiens)
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 3 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 98.48 Very High Very High Very High
Apoptosis 27 77.04 Quite High
Cancer 105 75.32 Quite High
Glioma 78 72.16 Quite High
Leukemia 3 54.24 Quite High
Retinoblastoma 3 35.76 Quite Low
Hyperplasia 6 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Colon Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Very recently, Li [60] reported the effect of anti-inflammatory drugs on proliferation of human osteoblasts with the increased activity of FOXO3a by binding to p27Kip1 promoter.
FOXO3a Binding (binding) of p27Kip1 in osteoblasts associated with inflammation and cinod
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.27 Pain Relevance 0.10
Thus, these findings invite the conclusion that the increased p27Kip1 expression with the treatments is due to the increased nuclear expression of FOXO3a, which binds to the -2984 bp region on the p27Kip1 promoter and could be mediated by the low expression of p-AKT.
FOXO3a Binding (binds) of p27Kip1
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.35 Pain Relevance 0.09
Recent data show FOXO3a directly regulates p27kip1 transcription [53], [54], suggesting that reduced p27kip1 levels after a proliferative stimulus may also be associated with FOXO3a.
FOXO3a Binding (associated) of p27kip1
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.22 Pain Relevance 0

General Comments

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