INT322553

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.79
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CASP8) cytoplasm (CASP8) cell-cell signaling (TNFSF10)
cytosol (CASP8) peptidase activity (CASP8) extracellular space (TNFSF10)
Anatomy Link Frequency
macrophages 1
cleavage 1
TNFSF10 (Homo sapiens)
CASP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 142 97.08 Very High Very High Very High
Cancer 250 92.60 High High
Colon Cancer 88 62.48 Quite High
Death 20 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical analysis confirmed that while macrophages inhibited TRAIL-induced activation of caspase 8 and caspase-9 and cleavage of PARP and ?
TRAIL Positive_regulation (activation) of caspase 8 in macrophages
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.14 Pain Relevance 0
failed to counteract TRAIL-induced activation of caspase-8 and caspase-9 and subsequent cleavage of PARP in cells that express either dnI?
TRAIL Positive_regulation (activation) of caspase-8 in cleavage
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.65 Pain Relevance 0

General Comments

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