INT322557

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF10) extracellular space (TNFSF10) extracellular region (TNFSF10)
nucleus (BIRC3) intracellular (BIRC3) cytoplasm (BIRC3)
TNFSF10 (Homo sapiens)
BIRC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 71 98.04 Very High Very High Very High
Cancer 125 92.84 High High
Intestinal Polyps 1 83.20 Quite High
Familial Adenomatous Polyposis 1 77.20 Quite High
Toxicity 1 70.96 Quite High
Colon Cancer 44 50.00 Quite Low
Death 10 45.44 Quite Low
Solid Tumor 1 7.20 Low Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, c-Myc promotes the responsiveness to TRAIL by inhibiting the expression of FLIP, an inhibitor of TRAIL signaling [15], and by counteracting TRAIL-induced upregulation of mcl-1 and cIAP2, two proteins with intrinsic ability to inhibit apoptosis [16].
TRAIL Positive_regulation (upregulation) of cIAP2 associated with apoptosis
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.27 Pain Relevance 0

General Comments

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