INT32256

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Context Info
Confidence 0.75
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 7.80
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLXNA3) plasma membrane (PLXNA3) intracellular (PLXNA3)
Anatomy Link Frequency
thyroid 2
follicle 1
pituitary 1
gonad 1
PLXNA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 70 99.36 Very High Very High Very High
Opioid 21 99.16 Very High Very High Very High
Fibrositis 14 98.74 Very High Very High Very High
alcohol 100 98.08 Very High Very High Very High
Migraine 9 97.88 Very High Very High Very High
Lasting pain 102 89.68 High High
Dismenorea 1 88.68 High High
methadone 3 86.48 High High
dexamethasone 1 82.40 Quite High
opiate 9 81.76 Quite High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 4 99.64 Very High Very High Very High
Pain 166 99.36 Very High Very High Very High
Sleep Disorders 5 98.74 Very High Very High Very High
Headache 5 97.88 Very High Very High Very High
Thyroid Disease 4 97.16 Very High Very High Very High
Metabolic Syndrome 7 96.76 Very High Very High Very High
Graves' Ophthalmopathy 2 96.48 Very High Very High Very High
Chronic Disease 1 95.96 Very High Very High Very High
Disease 4 95.92 Very High Very High Very High
Reprotox - General 3 6 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During treatment with propylthiouracil and levothyroxine, the plasma concentrations of thyroid hormone, sex hormones and sex hormone-binding globulin normalised and the gynaecomastia disappeared.
Gene_expression (concentrations) of sex in thyroid
1) Confidence 0.75 Published 2002 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 11851085 Disease Relevance 0.44 Pain Relevance 0.09
Serum testosterone levels and other sex hormones, including follicle-stimulating hormone, luteinizing hormone, sex-hormone-binding globulin, and prolactin, should be measured prior to and at various points during intraspinal opioid therapy.
Gene_expression (measured) of sex in follicle associated with opioid
2) Confidence 0.65 Published 1994 Journal J Pain Symptom Manage Section Abstract Doc Link 7517429 Disease Relevance 0.17 Pain Relevance 0.66
Female sex-hormones appear to be the key contributor to a higher prevalence of migraine in female.
Spec (appear) Gene_expression (appear) of sex associated with migraine
3) Confidence 0.65 Published 2008 Journal Neuroscience bulletin Section Abstract Doc Link 18369391 Disease Relevance 0.68 Pain Relevance 0.50
Other agents that use sex hormone receptors, such as selective estrogen receptor modulators and tibolone, also may affect sexual function.
Gene_expression (use) of sex
4) Confidence 0.65 Published 2005 Journal Semin. Reprod. Med. Section Abstract Doc Link 15852204 Disease Relevance 0.62 Pain Relevance 0.09
Similarly, dehydroepiandrosterone sulfate, sex hormone binding globulin, and gonadotrophin levels were unaltered after 6 months of treatment.
Gene_expression (levels) of sex
5) Confidence 0.58 Published 1986 Journal Cancer Res. Section Abstract Doc Link 2942241 Disease Relevance 0.55 Pain Relevance 0.08
Commonly prescribed opioids in sustained-action dosage forms usually produce subnormal sex hormone levels, which may contribute to a diminished quality of life for many patients with painful chronic illness.
Gene_expression (produce) of sex associated with pain, opioid and chronic disease
6) Confidence 0.58 Published 2002 Journal J Pain Section Abstract Doc Link 14622741 Disease Relevance 0.42 Pain Relevance 1.13
Serum GH, androgen, and 24-hour urinary cortisol levels of patients with fibromyalgia tend to be in the lower part of the normal range, while serum levels of thyroid hormone, female sex hormones, prolactin, and melatonin are normal.
Gene_expression (levels) of sex in thyroid associated with fibrositis
7) Confidence 0.58 Published 2002 Journal Rheum. Dis. Clin. North Am. Section Abstract Doc Link 12122926 Disease Relevance 0.59 Pain Relevance 0.29
Other factors such as increased estrogen production rate, increased activity of the opioid system and of the hypothalamic-pituitary-adrenal axis, decreased sex hormone binding globulin synthesis and, possibly, high dietary lipid intake, may be additional mechanisms by which obesity favours the development of hyperandrogenism in PCOS.
Gene_expression (synthesis) of sex in pituitary associated with polycystic ovary syndrome, metabolic syndrome, hyperandrogenism and opioid
8) Confidence 0.58 Published 2002 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 12080440 Disease Relevance 2.63 Pain Relevance 0.10
The possible relationship among headaches, lifestyle habits, and anesthetic technique, and the presence of PDPH were analyzed, as were the levels of female sex hormones with PDPH in comparison with a control group.
Gene_expression (levels) of sex
9) Confidence 0.58 Published 1998 Journal Reg Anesth Pain Med Section Body Doc Link 9773702 Disease Relevance 0.08 Pain Relevance 0
It appears that the prepubertal gonad is actively producing sex hormones which might be important in the control of GH production since early childhood.
Gene_expression (producing) of sex in gonad
10) Confidence 0.58 Published 1996 Journal Horm. Res. Section Abstract Doc Link 8742123 Disease Relevance 0 Pain Relevance 0.08
In terms of biological factors, the transmission and modulation of pain signals may differ in men and women.[5,6] Normal hormonal variations and changes related to women's reproductive functions can be sex-specific sources of pain, as can pathologic processes associated with these.[7] Psychologically, women may differ in their cognitive and emotional processing of pain and also behave differently when in pain.[4] Socially, women differ from men in their societal, family and occupational roles (e.g. multiple primary-role responsibilities), and these may also be potential sources of sex differences in pain.
Gene_expression (sources) of sex associated with pain, cognitive disorder and pathologic processes
11) Confidence 0.52 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC2096686 Disease Relevance 1.61 Pain Relevance 1.36
Having unprotected sex was independently associated with being married, not having a casual partner, methamphetamine use and having sex when high on drugs or alcohol (Table 4).
Gene_expression (unprotected) of sex associated with alcohol
12) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2988741 Disease Relevance 0 Pain Relevance 0.23
There was a statistically significant interaction between IDU and risky alcohol use (p = 0.009), in that non-IDUs who engaged in risky drinking had 6.7 greater odds of having unprotected sex than those who did not engage in risky drinking whereas there was no such relationship for IDUs.
Gene_expression (unprotected) of sex associated with alcohol
13) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2988741 Disease Relevance 0 Pain Relevance 0.30

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