INT322593

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.51
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural constituent of ribosome (RPS18) ribosome (RPS18) intracellular (RPS18)
ribosome biogenesis (RPS18) cytoplasm (RPS18) cytosol (RPS18)
Anatomy Link Frequency
macrophages 1
colon 1
RPS18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 69.04 Quite High
Inflammation 24 10.32 Low Low
cINOD 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 132 99.96 Very High Very High Very High
Apoptosis 213 98.44 Very High Very High Very High
Cancer 375 97.52 Very High Very High Very High
Shock 6 77.20 Quite High
Death 30 35.60 Quite Low
INFLAMMATION 18 10.32 Low Low
Acute Monocytic Leukemia 3 5.44 Low Low
Repression 6 5.00 Very Low Very Low Very Low
Breast Cancer 6 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to HCT116 and Hke-3 cells transfected with NSP(nontargeting) RNAi, cells transfected with Snail specific RNAi failed to respond to macrophages and IL-1?
Gene_expression (transfected) of Hke-3 in macrophages
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.62 Pain Relevance 0
Here we describe that macrophages protect HCT116 and Hke-3 colon cancer cells from TRAIL-induced apoptosis.
Gene_expression (protect) of Hke-3 in colon associated with colon cancer and apoptosis
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908545 Disease Relevance 1.18 Pain Relevance 0
There was no reproducible difference between the responsiveness of HCT116 and Hke-3 cells to TRAIL (Fig. 1 and 2), demonstrating that the presence of mutant kRas does not regulate the responsiveness of cells to TRAIL.
Gene_expression (responsiveness) of Hke-3
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.71 Pain Relevance 0.03

General Comments

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