INT322648

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 39
Disease Relevance 39.51
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pbrm1) DNA binding (Pbrm1)
Anatomy Link Frequency
terminal portion 2
livers 1
white blood cells 1
lungs 1
A549 1
Pbrm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 507 99.00 Very High Very High Very High
Inflammation 1287 98.94 Very High Very High Very High
cva 39 68.80 Quite High
anesthesia 39 5.00 Very Low Very Low Very Low
isoflurane 39 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 2886 100.00 Very High Very High Very High
Contagious Ecthyma 117 100.00 Very High Very High Very High
Death 1560 99.74 Very High Very High Very High
Infection 741 99.56 Very High Very High Very High
Influenza In Birds 195 99.46 Very High Very High Very High
Disease 312 99.44 Very High Very High Very High
Viral Infection 156 99.24 Very High Very High Very High
Apoptosis 702 99.12 Very High Very High Very High
INFLAMMATION 1638 98.94 Very High Very High Very High
Necrosis 156 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of PB1-F2 has been shown to enhance viral pathogenicity in mouse models of influenza A virus infection [9], [10].
Gene_expression (Expression) of PB1 associated with influenza virus infection and infection
1) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.65 Pain Relevance 0
Disruption of PB1-F2 expression in PR8 or replacement of the PR8 PB1-F2 with the C-terminally truncated Beij PB1-F2 both significantly reduced the number of white blood cells found in BALF 3 days post viral infection (Figure 5A) compared to PR8.
Gene_expression (expression) of PB1 in white blood cells associated with viral infection
2) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.10 Pain Relevance 0.24
PB1-F2 is expressed early in the course of infection [10] and has a short half-life [4].
Gene_expression (expressed) of PB1 associated with infection
3) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.03 Pain Relevance 0.19
However, effects of PB1-F2 on cell death have been contextual; the protein's apoptotic effects have been cell type specific, have differed dependent on infection with whole virus vs. expression of PB1-F2 alone, and to this point have only been studied using the laboratory strain PR8.
Gene_expression (expression) of PB1 associated with sprains and strains, apoptosis, infection and death
4) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.60 Pain Relevance 0.03
One additional caveat for these studies is that deletion of the PB1-F2 start codon has been shown to affect expression levels of a truncated version of PB1, the N40 protein [23].
Gene_expression (expression) of PB1
5) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.79 Pain Relevance 0.07
Although antibody is generated in humans which can recognize PB1-F2 [7], it is not known whether this can modulate the functional outcomes of PB1-F2 expression and decrease disease.
Gene_expression (expression) of PB1 associated with disease
6) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.91 Pain Relevance 0.13
Evidence presented here implicates full length PB1-F2 protein expression, encoded by a +1 open reading frame of the PB1 gene segment, as a marker of pathogenicity of 20th century pandemic strains.
Gene_expression (expression) of PB1 associated with sprains and strains
7) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.23 Pain Relevance 0.10
However, the differential effects of PB1-F2 expression could clearly be seen in the inflammatory response in the lungs.
Gene_expression (expression) of PB1 in lungs associated with inflammatory response
8) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.18 Pain Relevance 0.22
Full length PB1-F2 proteins are expressed by nearly all avian influenza virus strains [16], but analysis of lineages after introduction of these strains into humans or pigs show evidence of permanent truncation during adaptation in mammalian hosts.
Gene_expression (expressed) of PB1 associated with influenza in birds and sprains and strains
9) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.22 Pain Relevance 0.15
This panel included previously described viruses unable to express PB1-F2 (?
Neg (unable) Gene_expression (express) of PB1
10) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.16 Pain Relevance 0
Expression of the 1918 PB1-F2 led to effects similar to those of the PR8 virus.
Gene_expression (Expression) of PB1
11) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.90 Pain Relevance 0.23
Use of the virus containing the H5N1 PB1 gene segment in a PR8 background revealed that disruption of PB1-F2 expression also significantly depressed the inflammatory response compared to the virus maintaining the ability to express full length PB1-F2 (Figure 5A, B, C).
Gene_expression (express) of PB1 associated with inflammatory response
12) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.78 Pain Relevance 0.23
Recent seasonal H1N1 strains express a form of PB1-F2 truncated after 57 amino acids, lacking the mitochondrial targeting sequence located in the C-terminal region, and thus could not be evaluated in this manner [15], [16].
Gene_expression (express) of PB1 associated with sprains and strains
13) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.31 Pain Relevance 0
Indeed, data published while this manuscript was in revision indicate that genetic reversion of the stop codons of the pandemic H1N1 strains to produce full length PB1-F2 has only minimal effects on virulence and support for secondary bacterial infections [31].
Gene_expression (produce) of PB1 associated with bacterial infection and sprains and strains
14) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.88 Pain Relevance 0.05
PB1-F2/PR8), or expressing the PB1-F2 of the 1918 pandemic strain (1918 PB1-F2/PR8) or the truncated 1956 H1N1 strain (Beij PB1-F2/PR8) [10], [15].
Gene_expression (expressing) of PB1 associated with sprains and strains
15) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.22 Pain Relevance 0
In addition, deletion of PB1-F2 in either an H3N2 or H5N1 PB1 gene segment background did not alter the cell death phenotype of chimeric viruses expressing those PB1s.
Gene_expression (expressing) of PB1s associated with death
16) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.18 Pain Relevance 0
To test this hypothesis, we exposed isolated mitochondria obtained from the livers of BALBcJ mice to various concentrations of PR8 derived PB1-F2 peptide.
Gene_expression (derived) of PB1 in livers
17) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.59 Pain Relevance 0
PB1-F2/PR8 to express PB1-F2 and the truncation of the C-terminal portion of Beij PB1-F2/PR8 abrogated the ability of both viruses to cause cell death in both cell types (Figure 2C, D).
Gene_expression (express) of PB1 in terminal portion associated with death
18) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.29 Pain Relevance 0
Using confocal microscopy we demonstrated that PB1-F2 proteins from the viruses which were utilized in this study and which have an intact PB1-F2 ORF are expressed and distribute throughout the cell (Figure S2; Text S2) and [15].
Gene_expression (expressed) of PB1 associated with contagious ecthyma
19) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.30 Pain Relevance 0
PB1-F2/PR8), or expressing the PB1-F2 of the 1918 pandemic strain (1918 PB1-F2/PR8) or the truncated 1956 H1N1 strain (Beij PB1-F2/PR8) [10], [15].
Gene_expression (expressing) of PB1 associated with sprains and strains
20) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.16 Pain Relevance 0

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