INT322672

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.87
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SLC25A6) small molecule metabolic process (SLC25A6) nucleus (Pbrm1)
DNA binding (Pbrm1) transmembrane transport (SLC25A6)
Anatomy Link Frequency
pore 1
SLC25A6 (Homo sapiens)
Pbrm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 26 65.28 Quite High
Inflammation 66 33.08 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 80 100.00 Very High Very High Very High
Apoptosis 36 100.00 Very High Very High Very High
Targeted Disruption 4 97.36 Very High Very High Very High
Influenza Virus Infection 52 93.64 High High
Sprains And Strains 148 90.16 High High
Disease 16 82.28 Quite High
Stress 2 69.52 Quite High
Infection 38 67.16 Quite High
INFLAMMATION 84 64.88 Quite High
Contagious Ecthyma 6 40.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been suggested that PB1-F2 is able to induce cell death by disrupting mitochondrial organization through interaction with inner mitochondrial membrane adenine nucleotide translocator 3 (ANT3) and the outer mitochondrial membrane voltage channel 1 (VDAC1) to produce a mitochondrial permeability transition [12].
ANT3 Binding (interaction) of PB1 associated with death
1) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.08 Pain Relevance 0
Since its discovery the consensus has been that the PB1-F2 proteins from selected viruses are pro-apoptotic, targeting the mitochondria and inducing pore formation through association with VDAC1 and ANT3 [4], [11], [12], [19], [24].
ANT3 Binding (association) of PB1 in pore associated with apoptosis
2) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.79 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox