INT322712

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.29
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
leukocyte 2
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 84 100.00 Very High Very High Very High
agonist 3 98.40 Very High Very High Very High
antagonist 27 86.64 High High
Inflammation 61 61.44 Quite High
Inflammatory mediators 1 48.80 Quite Low
tolerance 12 44.16 Quite Low
Intracerebroventricular 3 40.24 Quite Low
Inflammatory response 4 38.96 Quite Low
ischemia 9 31.60 Quite Low
Inflammatory marker 23 13.32 Low Low
Disease Link Frequency Relevance Heat
Renal Disease 6 99.92 Very High Very High Very High
Diabetes Mellitus 24 99.04 Very High Very High Very High
Endometriosis (extended) 1 97.40 Very High Very High Very High
Herpes Simplex Virus 6 90.48 High High
Sarcoma 3 89.28 High High
Diabetic Angiopathy 1 75.88 Quite High
Pathologic Processes 1 69.76 Quite High
Myocardial Infarction 8 66.52 Quite High
INFLAMMATION 89 61.44 Quite High
Graft Vs Host Disease 3 61.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study the association between MCP-1 and abnormal glucose regulation was present in the majority of the patients, but not in patients with triglycerides above 1.8 mmol/L, suggesting that in these patients the high levels of triglycerides may mask the association between MCP-1 and glucose regulation.
Negative_regulation (present) of MCP-1 Binding (association) of
1) Confidence 0.32 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.66 Pain Relevance 0.03
Furthermore, vMIP-II inhibits the chemotactic activity of the rat chemokines CCL2 (MCP-1), CCL4 (MIP-1?)
Negative_regulation (inhibits) of CCL2 Binding (activity) of associated with chemokine
2) Confidence 0.29 Published 2010 Journal World J Urol Section Body Doc Link PMC2908759 Disease Relevance 0.18 Pain Relevance 0.52
Other groups reported that gene transfer of plasmid DNA encoding vMIP-II into murine cardiac allografts resulted in a prolonged survival time of allografts and a marked decrease in donor-specific cytotoxic T lymphocytes (CTL) infiltrating the grafts with an inhibition of alloantibody production [8]. vMIP-II administration has been reported to reduce leukocyte infiltration and glomerulitis in an experimental model of glomerulonephritis by reducing the chemotactic activity of MCP-1, MIP-1?
Negative_regulation (reducing) of MCP-1 Binding (activity) of in leukocyte associated with renal disease
3) Confidence 0.29 Published 2010 Journal World J Urol Section Body Doc Link PMC2908759 Disease Relevance 0.27 Pain Relevance 0.37
Furthermore, vMIP-II inhibits the chemotactic activity of the rat chemokines CCL2 (MCP-1), CCL4 (MIP-1?)
Negative_regulation (inhibits) of MCP-1 Binding (activity) of associated with chemokine
4) Confidence 0.29 Published 2010 Journal World J Urol Section Body Doc Link PMC2908759 Disease Relevance 0.18 Pain Relevance 0.52

General Comments

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