INT322734

Context Info Confidence 0.07 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.62 Pain Relevance 0.18

extracellular region (CD40LG, CD40) plasma membrane (CD40LG, CD40) signal transduction (CD40) extracellular space (CD40LG) enzyme binding (CD40) protein complex assembly (CD40)

Anatomy Link Frequency T-cell 2 CD40LG (Homo sapiens) CD40 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 7 99.56 cytokine 2 99.04 Botox 2 39.68 anesthesia 1 5.00 ischemia 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 7 99.56 Hyperthyroidism 3 84.56 Thyroid Disease 36 73.88 Hypothyroidism 1 73.20 Graves' Ophthalmopathy 23 70.80 Disease 5 67.28 Injury 4 44.32 Diplopia 9 32.08 Cataract 6 30.88 Pressure And Volume Under Development 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Orbital fibroblasts in particular are neural crest derived17 and express CD40 (a typical B-cell cell surface receptor) that can be activated by T-cell receptor (CD154) linkage to elicit inflammatory cytokines and bone marrow derived cell migration factors.18,19

CD154 Binding (linkage) of in T-cell Positive_regulation (activated) of CD40 associated with inflammation and cytokine

1) Confidence 0.07 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908832 Disease Relevance 0.62 Pain Relevance 0.18

General Comments

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