INT322765

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.21
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB11) small molecule metabolic process (ABCB11) ATPase activity (ABCB11)
plasma membrane (ABCB11) transmembrane transport (ABCB11)
Anatomy Link Frequency
bile 2
ABCB11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 4 100.00 Very High Very High Very High
Paracetamol 2 90.32 High High
agonist 33 50.00 Quite Low
Inflammation 2 48.40 Quite Low
cytokine 3 40.88 Quite Low
Potency 13 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 191 99.72 Very High Very High Very High
Gallstones 1 98.88 Very High Very High Very High
Hepatotoxicity 23 92.84 High High
Apoptosis 11 92.24 High High
Injury 2 65.04 Quite High
INFLAMMATION 5 48.40 Quite Low
Cancer 9 39.44 Quite Low
Necrosis 1 38.96 Quite Low
Obesity 43 27.20 Quite Low
Diabetes Mellitus 22 26.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another mechanism of toxicity could be the inhibition of the activity of the bile salt export pump (BSEP or ABCB11), which is responsible for cholestasis [39].
Negative_regulation (inhibition) of ABCB11 in bile associated with toxicity, bile and gallstones
1) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.77 Pain Relevance 0.14
Human bile salt export pumps (BSEP) can be a target for some drugs and chemicals; therefore, inhibition of BSEP can result in hepatobiliary as well as generalized toxicity [22].
Negative_regulation (inhibition) of BSEP in bile associated with toxicity and bile
2) Confidence 0.12 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.44 Pain Relevance 0.10

General Comments

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