INT322809

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (RS1) transport (GRIA3) extracellular region (RS1)
cell adhesion (RS1) plasma membrane (GRIA3) protein complex (GRIA3)
GRIA3 (Homo sapiens)
RS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 6 97.84 Very High Very High Very High
Glutamate 13 94.36 High High
Migraine 46 85.20 High High
Central nervous system 3 67.12 Quite High
Neurotransmitter 3 65.92 Quite High
Glutamate receptor 7 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
trigeminal ganglion 1 5.00 Very Low Very Low Very Low
central sensitization 1 5.00 Very Low Very Low Very Low
Thalamus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 6 97.84 Very High Very High Very High
Epilepsy 5 96.28 Very High Very High Very High
Headache 45 85.20 High High
Disease 5 5.00 Very Low Very Low Very Low
Migraine With Aura 3 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two variants in the regulative regions of GRIA1 (rs2195450) and GRIA3 (rs3761555) genes resulted strongly associated with MA (P = 0.00002 and P = 0.0001, respectively), but not associated with MO, suggesting their role in cortical spreading depression.
GRIA3 Binding (associated) of rs2195450 associated with depression
1) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2909201 Disease Relevance 0.43 Pain Relevance 0.51

General Comments

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