INT322810

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC12A1, GRIA1) signal transduction (GRIA1) transport (SLC12A1)
endoplasmic reticulum (GRIA1) transmembrane transport (SLC12A1)
SLC12A1 (Homo sapiens)
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 46 95.44 Very High Very High Very High
Glutamate receptor 7 55.52 Quite High
Glutamate 13 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
trigeminal ganglion 1 5.00 Very Low Very Low Very Low
central sensitization 1 5.00 Very Low Very Low Very Low
Thalamus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 45 95.44 Very High Very High Very High
Migraine With Aura 3 65.44 Quite High
Stress 1 52.00 Quite High
Depression 6 5.00 Very Low Very Low Very Low
Epilepsy 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More complex is the case of GRIA1 gene where only the -2012C>T variant seems to affect the binding affinity of the GRIA1 promoter with transcription factor(s) and the variant T allele has a stronger binding strength compared with the C allele.
variant Spec (seems) Regulation (affect) of GRIA1 Binding (affinity) of
1) Confidence 0.00 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.39 Pain Relevance 0.36

General Comments

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