INT322816

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Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.75
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIA3) plasma membrane (GRIA3) protein complex (GRIA3)
Anatomy Link Frequency
covering 1
cerebellum 1
GRIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 12 98.60 Very High Very High Very High
nMDA receptor 25 93.36 High High
Glutamate 34 84.92 Quite High
Migraine 46 83.52 Quite High
agonist 2 67.52 Quite High
nMDA receptor antagonist 2 46.40 Quite Low
Dopamine 1 32.24 Quite Low
anticonvulsant 5 18.20 Low Low
Lamotrigine 1 17.44 Low Low
amygdala 58 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autism 314 99.06 Very High Very High Very High
Headache 45 83.52 Quite High
Stress 10 76.60 Quite High
Attention Deficit Hyperactivity Disorder 11 37.72 Quite Low
Influenza Virus Infection 1 34.44 Quite Low
Aging 1 32.08 Quite Low
Migraine With Aura 3 13.20 Low Low
Anxiety Disorder 52 5.00 Very Low Very Low Very Low
Cognitive Disorder 43 5.00 Very Low Very Low Very Low
Intellectual Impairment 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that the T-allele displays lower promoter transcription activity, we infer that the nuclear factor(s) bound to the region covering the -1952T>C polymorphism may function as negative regulator(s) for GRIA3 transcription.
Transcription (transcription) of GRIA3 in covering
1) Confidence 0.71 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.36 Pain Relevance 0.28
One post-mortem study compared glutamate receptor expression in autistic and control brains and revealed that the mRNA levels of the AMPA receptors GluR1, GluR2, and GluR3 were increased in the cerebellum of autistics.
Transcription (levels) of GluR3 in cerebellum associated with autism and glutamate receptor
2) Confidence 0.09 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.39 Pain Relevance 0.42

General Comments

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